Lycopene, a non-provitamin A carotenoid, is the reason for redness in tomatoes and some other vegetables. Lycopene has also been known as one fat-soluble red pigment that is produced by plants and some microorganisms. Nowadays, the effects of lycopene on healthiness have recently been significantly interested. Antioxidant properties of lycopene have been received attention as an anticancer. Different studies have investigated the effects of lycopene in relation to different cancers types. Lycopene significantly shows powerful anticancer activity against prostate cancer, even in progressed and aggressive condition. This review article aims to introduce the lycopene and possible mechanisms for the treatment of cancer.