Background and purpose: Natural agents have been used for protection against damages. This study was conducted to evaluate the effects of dietary supplementing of resveratrol on antioxidant status improvement in hypercholestrolemic rats with Plasmodium berghei. Methods: Rats were divided into 6 groups including rats fed with basal diet (Control group), basal diet containing resveratrol 2.5 mg/kg (2.5 RES), basal diet containing 5.0 mg/kg of resveratrol (5.0 RES), basal diet containing 1% cholesterol + 0.5% cholic acid (Control HC), basal diet containing 2.5 mg/kg of resveratrol and 1% cholesterol + 0.5% cholic acid (2.5 RES-HC), basal diet containing resveratrol 5.0 mg/kg and 1% cholesterol + 0.5% cholic acid (5.0 RES-HC). The plasma levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), malondialdehyde (MDA), and low density lipoprotein (LDL) and expression levels of glutathione peroxidase (GPx), glutathione reductase (GR), paraoxonase-1 and sulfiredoxin-1 were assessed.
Results: The plasma concentrations of cholesterol, triglycerides, LDL-C and malondialdehyde were significantly higher and level of HDL was significantly lower in hypercholesterolemic rats, but dietary supplementation with resveratrol significantly improved them (P<0.05). Hypercholesterolemic rats showed a decrease in GPx and GR and an increase in paraoxonase-1 and sulfiredoxin-1 compared to the healthy control (P<0.05), but applying resveratrol improved the adverse effects of hypercholesterolemia on mentioned parameters (P<0.05). Conclusion: Resveratrol can be used for treatment of patients with hypercholesterolemia.