Coronavirus disease 2019 (COVID-19) had affected both developed and developing countries too. The first case in Nepal was confirmed on 23 January 2020. It was also the first recorded case of COVID-19 in South Asia. Nepal reported its first Covid-19 death on May 16. At the end of August, the number of death stood 228 which went up to 498 at the end of September and 937 at the end of October and 1126 on 9 November. In September and October, deaths doubled, and with winter setting in, fatalities may skyrocket. Among the total CP cases in Nepal nearly 50 percent are from the Capital Kathmandu. So, Kathmandu is the new epicenter of COVID-19 in Nepal. Despite limited resources, the government's major challenges are early diagnosis, management of confirmed cases, contact tracing, and implementing some public health measures to reduce the infection's transmissibility.