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Volume 2, Issue 2 (2023)
GMJM 2023, 2(2): 67-70 |
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Received: 2022/10/29 | Accepted: 2023/02/25 | Published: 2023/04/14
Received: 2022/10/29 | Accepted: 2023/02/25 | Published: 2023/04/14
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Nasseri A, Mahdavi F. Effect of Intravenous Infusion of Magnesium Sulfate on Opioid Use to Reduce Pain After Laparotomy in Patients with a History of Radiotherapy. GMJM 2023; 2 (2) :67-70
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A. Nasseri *1, F. Mahdavi1
1- Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract (676 Views)
Aims: Due to the adverse effects of injectable opioids after surgery and the suggestions of many researchers to find a reliable way to replace opioid use and also the contradictory results of the most appropriate method of using magnesium sulfate to control and reduce postoperative pain, this study was to evaluate the effect of intravenous infusion of magnesium sulfate on opioid use on reduce pain after laparotomy in patients with a history of radiotherapy.
Instrument & Methods: In this descriptive cross-sectional study, 50mg/kg of bolus magnesium sulfate was injected before surgery; then, after the end of surgery, 500mg/hr of the same drug was injected. Pain intensity was assessed in patients in two different groups.
Findings: No statistically significant relationship was observed in the hemodynamic status of patients in both groups before, during and after surgery. The rate of drug use in the intervention group was associated with a decrease over time, while no significant reduction was seen in the control group. Also, no statistically significant relationship was observed between the two groups after surgery.
Conclusion: Using magnesium sulfate, although it is effective in reducing the need for opioids in laparotomy patients with a history of radiotherapy, but can not reduce the need for opioids to zero.
Instrument & Methods: In this descriptive cross-sectional study, 50mg/kg of bolus magnesium sulfate was injected before surgery; then, after the end of surgery, 500mg/hr of the same drug was injected. Pain intensity was assessed in patients in two different groups.
Findings: No statistically significant relationship was observed in the hemodynamic status of patients in both groups before, during and after surgery. The rate of drug use in the intervention group was associated with a decrease over time, while no significant reduction was seen in the control group. Also, no statistically significant relationship was observed between the two groups after surgery.
Conclusion: Using magnesium sulfate, although it is effective in reducing the need for opioids in laparotomy patients with a history of radiotherapy, but can not reduce the need for opioids to zero.
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References
1. Lirk P, Rathmell JR. Opioid-free anaesthesia: Con: it is too early to adopt opioid-free anaesthesia today. Eur J Anaesthesiol. 2019;36:250-4. [Link] [DOI:10.1097/EJA.0000000000000965]
2. Soghomonyan S, Stoicea N, Sandhu GS, Pasternak JJ, Bergese SD. The role of permissive and induced hypotension in current neuroanesthesia practice. Front Surg. 2017;4:1-10. [Link] [DOI:10.3389/fsurg.2017.00001]
3. Nielsen FH. Magnesium deficiency and increased inflammation: current perspectives. J Inflamm. Res. 2018;11:25-34. [Link] [DOI:10.2147/JIR.S136742]
4. Dunn LK, Durieux ME. Perioperative use of intravenous lidocaine. Anesthesiology. 2017;126:729-37. [Link] [DOI:10.1097/ALN.0000000000001527]
5. Chowdhury S, Chanda B. Sodium channels caught in the act. Science. 2019;363:1278-9. [Link] [DOI:10.1126/science.aaw8645]
6. Chang YC, Liu CL, Liu TP, Yang PS, Chen MJ, Cheng SP. Effect of perioperative intravenous lidocaine infusion on acute and chronic pain after breast surgery: A meta-analysis of randomized controlled trials. Pain Pract. 2017;17:336-43. [Link] [DOI:10.1111/papr.12442]
7. Kim MH, Lee KY, Park S, Kim SI, Park HS, Yoo YC. Effects of systemic lidocaine versus magnesium administration on postoperative functional recovery and chronic pain in patients undergoing breast cancer surgery: A prospective, randomized, double-blind, comparative clinical trial. PLoS One. 2017;12:e0173026. [Link] [DOI:10.1371/journal.pone.0173026]
8. Couceiro TCM, Lima LC, Burle LMC, Valença MM. Lidocaína intravenosa no tratamento da dor pós‐mastectomia: ensaio clínico aleatório encoberto placebo controladoIntravenous lidocaine for post‐mastectomy pain treatment: randomized, blind, placebo controlled clinical trial. Rev Bras Anestesiol. 2015;65:207-12. [Link] [DOI:10.1016/j.bjan.2014.05.016]
9. Weibel S, Jelting Y, Pace NL, Helf A, Eberhart LH, Hahnenkamp K, et al. Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery in adults. Cochrane Database Syst Rev. 2018;6:CD009642. [Link] [DOI:10.1002/14651858.CD009642.pub3]
10. Ho MLJ, Kerr SJ, Stevens J. Intravenous lidocaine infusions for 48 hours in open colorectal surgery: a prospective, randomized, double-blinded, placebo-controlled trial. Korean J Anesthesiol. 2018;71:57-65. [Link] [DOI:10.4097/kjae.2018.71.1.57]
11. Dewinter G, Moens P, Fieuws S, Vanaudenaerde B, de Velde MV, Rex S. Systemic lidocaine fails to improve postoperative morphine consumption, postoperative recovery and quality of life in patients undergoing posterior spinal arthrodesis. A double-blind, randomized, placebo-controlled trial. Br J Anaesth. 2017;118:576-85. [Link] [DOI:10.1093/bja/aex038]
12. Miró J, Castarlenas E, de la Vega R, Solé E, Tomé‐Pires C, Jensen MP, et al. Validity of three rating scales for measuring pain intensity in youths with physical disabilities. Eur J Pain. 2016;20:130-7. [Link] [DOI:10.1002/ejp.704]
13. Mendonca FT, Reis MC, Aguiar JA, Calvano LA. Systemic lidocaine for perioperative analgesia: A literature review. J Anesth Intensive Care Med. 2015;1:1-8. [Link] [DOI:10.19080/JAICM.2015.01.555551]
14. Rawal N. Current issues in postoperative pain management. Eur J Anaesthesiol. 2016;33:160-71. [Link] [DOI:10.1097/EJA.0000000000000366]
15. Ashmawi HA, Freire GMG. Sensibilização periférica e central. Rev Dor. 2016;17:31-4. [Portuguese [Link] [DOI:10.5935/1806-0013.20160044]