GMJ Medicine
eISSN : 2626-3041
Embase
Biosis Previews
description
Volume 2, Issue 4 (2023)
GMJM 2023, 2(4): 127-131 |
Back to browse issues page
Article Type:
Subject:
History
Received: 2023/05/1 | Accepted: 2023/11/5 | Published: 2023/12/14
Received: 2023/05/1 | Accepted: 2023/11/5 | Published: 2023/12/14
How to cite this article
Saboktakin L. Relationship Between Hypothyroidism and Body Mass Index in Children. GMJM 2023; 2 (4) :127-131
URL: http://gmedicine.de/article-2-208-en.html
URL: http://gmedicine.de/article-2-208-en.html
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Rights and permissions
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Authors
L. Saboktakin *
“Tuberculosis and Lung Disease Research Center” and “Department of Otorhinolaryngology”, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract (678 Views)
Aims: In some studies, obesity has been linked to pediatric thyroid disorders; This relationship can lead to many risks in children; Because both of these diseases have side effects that can occur more severely together; High blood pressure, disorders of the immune system, as well as cardiovascular disease occur in children who are obese and have thyroid disorders 16 times more often than normal children; The aim of this study was the relationship between hypothyroidism and body mass index in children.
Instrument & Methods: This is a cross-sectional descriptive study that was conducted during 2019 in Tabriz General Medical University with the participation of 100 children. Demographic information, body mass index, T4, TF4, T3 and FT3 were recorded for all children and the relationship between body mass index and thyroid test status was assessed.
Findings: The children participating in the study were divided according to body mass index. They were also divided according to the amount of thyroid hormones. The results showed that the higher the body mass index, the lower the thyroid hormones; In other words, the results showed that hypothyroidism leads to obesity in children.
Conclusion: In all cases of subclinical hypothyroidism in children, following which thyroid function returns to normal, re-evaluation at older ages, especially during adolescence or pregnancy, is necessary.
Instrument & Methods: This is a cross-sectional descriptive study that was conducted during 2019 in Tabriz General Medical University with the participation of 100 children. Demographic information, body mass index, T4, TF4, T3 and FT3 were recorded for all children and the relationship between body mass index and thyroid test status was assessed.
Findings: The children participating in the study were divided according to body mass index. They were also divided according to the amount of thyroid hormones. The results showed that the higher the body mass index, the lower the thyroid hormones; In other words, the results showed that hypothyroidism leads to obesity in children.
Conclusion: In all cases of subclinical hypothyroidism in children, following which thyroid function returns to normal, re-evaluation at older ages, especially during adolescence or pregnancy, is necessary.
Keywords:
| | Full-Text (HTML) (123 Views)
References
1. Rumińska M, Witkowska-Sędek E, Majcher A, Pyrżak B. Thyroid function in obese children and adolescents and its association with anthropometric and metabolic parameters. Adv Exp Med Boil. 2016;912:33-41. [Link] [DOI:10.1007/5584_2016_232]
2. Unüvar T, Anık A, Catlı G, Esen I, Abacı A, Büyükgebiz A, et al. Isolated hyperthyrotropinemia in childhood obesity and its relation with metabolic parameters. J Endocrinol Invest. 2014;37(9):799-804. [Link] [DOI:10.1007/s40618-014-0100-y]
3. Dahl M, Ohrt JD, Fonvig CE, Kloppenborg JT, Pedersen O, Hansen T, et al. Subclinical hypothyroidism in danish lean and obese children and adolescents. J Clin Res Pediatr Endocrinol. 2017;9(1):8-16. [Link] [DOI:10.4274/jcrpe.3319]
4. Ghergherehchi R, Hazhir N. Thyroid hormonal status among children with obesity. Ther Adv Endocrinol Metab. 2015;6(2):51-5. [Link] [DOI:10.1177/2042018815571892]
5. Damiano F, Rochira A, Gnoni A, Siculella L. Action of thyroid hormones, t3 and t2, on hepatic fatty acids: differences in metabolic effects and molecular mechanisms. Int J Mol Sci. 2017;18(4):744. [Link] [DOI:10.3390/ijms18040744]
6. Zeng X, Zhang Y, Kwong JS, Zhang C, Li S, Sun F, et al. The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: a systematic review. J. Evid. Based Med. 2015;8(1):2-10. [Link] [DOI:10.1111/jebm.12141]
7. Peeters RP, Engl N. Subclinical hypothyroidism. Mass Med Soc. 2017;376:2556-65. [Link] [DOI:10.1056/NEJMcp1611144]
8. Sun X, Sun Y, Li WC, Chen CY, Chiu YH, Chien HY, et al. Association of thyroid-stimulating hormone and cardiovascular risk factors. Intern Med. 2015;54(20):2537-44. [Link] [DOI:10.2169/internalmedicine.54.4514]
9. Styne DM, Arslanian SA, Connor EL, Farooqi IS, Murad MH, Silverstein JH, et al. Pediatric obesity-assessment, treatment, and prevention: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2017;102(3):709-57. [Link] [DOI:10.1210/jc.2016-2573]
10. Muntner P, Shimbo D, Carey RM, Charleston JB, Gaillard T, Misra S, et al. measurement of blood pressure in humans: a scientific statement from the American heart association. Hypertension 2019;73(5):e35-66. [Link] [DOI:10.1161/HYP.0000000000000087]
11. Guo Z, Li M, Han B, Qi X. Association of non-alcoholic fatty liver disease with thyroid function: A systematic review and meta-analysis. Dig Liver Dis. 2018;50(11):1153-62. [Link] [DOI:10.1016/j.dld.2018.08.012]
12. Kaltenbach TE, Graeter T, Oeztuerk S, Holzner D, Kratzer W, Wabitsch M, et al. Thyroid dysfunction and hepatic steatosis in overweight children and adolescents. Pediatr Obes. 2017;12(1):67-74. [Link] [DOI:10.1111/ijpo.12110]
13. Rumińska M, Witkowska-Sędek E, Majcher A, Pyrżak B. Thyroid function in obese children and adolescents and its association with anthropometric and metabolic parameters. Adv Exp Med Biol. 2016;912:33-41. [Link] [DOI:10.1007/5584_2016_232]
14. Licenziati MR, Valerio G, Vetrani I, De Maria G, Liotta F, Radetti G. Altered Thyroid function and structure in children and adolescents who are overweight and obese: reversal after weight loss. J Clin Endocrinol Metab. 2019;104(11):2757-65. [Link] [DOI:10.1210/jc.2018-02399]
15. Saboktakin L, Bilan N, Ghalehgolab Behbahan A, Poorebrahim S. Relationship between resistin levels and sepsis among children under 12 years of age: A case control study. Front Pediatr. 2019;7:355. [Link] [DOI:10.3389/fped.2019.00355]
16. Krause AJ, Cines B, Pogrebniak E, Sherafat‐Kazemzadeh R, Demidowich AP, Galescu OA, et al. Associations between adiposity and indicators of thyroid status in children and adolescents. Pediatr Obes. 2016;11(6):551-8. [Link] [DOI:10.1111/ijpo.12112]
17. Dahl M, Ohrt JD, Fonvig CE, Fonvig CE, Kloppenborg JT, Pedersen O, et al. Subclinical hypothyroidism in danish lean and obese children and adolescents. J Clin Res Pediatr Endocrinol. 2017;9(1):8-16. [Link] [DOI:10.4274/jcrpe.3319]
18. Thiagarajan S, Arun Babu T, Balaji R. Subclinical hypothyroidism in obese south Indian children. Indian J Pediatr. 2019;86(7):662. [Link] [DOI:10.1007/s12098-019-02966-9]
19. Fröhlich E, Wahl R. Thyroid autoimmunity: role of anti-thyroid antibodies in thyroid and extra-thyroidal diseases. Front Immunol. 2017;9:521. [Link] [DOI:10.3389/fimmu.2017.00521]
20. Singh R. Does one size fit everyone? replacement dose of levothyroxine in long-standing primary hypothyroidism in adults. Indian J Endocrinol Metab. 2017;21(3):404-9. [Link] [DOI:10.4103/ijem.IJEM_502_16]
21. Duntas LH, Jonklaas J. Levothyroxine dose adjustment to optimise therapy throughout a patient's lifetime. Adv Ther. 2019;36(2):30-46. [Link] [DOI:10.1007/s12325-019-01078-2]
22. Küme T, Acar S, Tuhan H, Çatlı G, Anık A, Gürsoy Çalan O, Böber E, et al. The relationship between serum zonulin level and clinical and laboratory parameters of childhood obesity. J Clin Res Pediatr Endocrinol. 2017;9(1):31-8. [Link] [DOI:10.4274/jcrpe.3682]
23. Khaleghi S, Ju JM, Lamba A, Murray JA. The potential utility of tight junction regulation in celiac disease: focus on larazotide acetate. Therap Adv Gastroenterol. 2016;9(1):37-49. [Link] [DOI:10.1177/1756283X15616576]
24. Sturgeon C, Lan J, Fasano A. Zonulin transgenic mice show altered gut permeability and increased morbidity/mortality in the DSS colitis model. Ann N Y Acad Sci. 2017;1397(1):130-42. [Link] [DOI:10.1111/nyas.13343]
25. Virili C, Fallahi P, Antonelli A, Benvenga S, Centanni M. Gut microbiota and Hashimoto's thyroiditis. Endocr Metab Disord. 2018;19(4):293-300. [Link] [DOI:10.1007/s11154-018-9467-y]
26. Virili C, Centanni M. Does microbiota composition affect thyroid homeostasis?. Endocrine. 2015;49(3):583-7. [Link] [DOI:10.1007/s12020-014-0509-2]