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Volume 3, Issue 4 (2024)
GMJM 2024, 3(4): 133-137 |
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Received: 2024/05/3 | Accepted: 2024/10/15 | Published: 2024/12/7
Received: 2024/05/3 | Accepted: 2024/10/15 | Published: 2024/12/7
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Bakhtiari A, Aboudzadeh S, Vaziri S, Mirzaei Roozbahani M. Efficiency of Probiotics in Immobilized Rats through Involvement of the Antioxidant and Anti-Inflammatory Systems. GMJM 2024; 3 (4) :133-137
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1- Department of Internal Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
2- Imam Ali Health Center, Abadan University of Medical Sciences, Abadan, Iran
3- Student Research Committee, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
4- Department of General Surgery, Lorestan University of medical Sciences, Khorramabad, Iran
2- Imam Ali Health Center, Abadan University of Medical Sciences, Abadan, Iran
3- Student Research Committee, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
4- Department of General Surgery, Lorestan University of medical Sciences, Khorramabad, Iran
Abstract (645 Views)
Aims: Immobilization is known as a type of stress that influences antioxidant status and inflammation factors. On the other hand, probiotics could significantly improve antioxidant status and inflammatory response. This study was thus conducted to evaluate the effects of probiotics in immobilized rats by involving antioxidant and anti-inflammatory systems.
Materials & Methods: A total number of 72 Albino Wistar rats were divided into 3 groups, including a normal control group without stress (Control), 2) Immobilized rats without additive (Immobilized), and 3) Immobilized rats given with 104 CFU probiotics.day-1(Probiotic). Inflammatory and pro-inflammatory cytokines, corticosterone, and serum antioxidants were evaluated on days 7 and 14.
Findings: Results showed that immobilization could significantly increase the serum concentrations of TNF-α, TGF-β corticosterone, MDA, and NO and also decrease SOD, GPx, and IL-10 in days 7 and 14, as immobilized rats were compared with control rats (p<0.05). However, administration of probiotics could significantly improve the above-mentioned parameters (p<0.05).
Conclusion: The use of probiotics could alleviate the adverse effects of stress. It could be advised to use probiotics in the form of dairy and other supplements to overcome stress.
Materials & Methods: A total number of 72 Albino Wistar rats were divided into 3 groups, including a normal control group without stress (Control), 2) Immobilized rats without additive (Immobilized), and 3) Immobilized rats given with 104 CFU probiotics.day-1(Probiotic). Inflammatory and pro-inflammatory cytokines, corticosterone, and serum antioxidants were evaluated on days 7 and 14.
Findings: Results showed that immobilization could significantly increase the serum concentrations of TNF-α, TGF-β corticosterone, MDA, and NO and also decrease SOD, GPx, and IL-10 in days 7 and 14, as immobilized rats were compared with control rats (p<0.05). However, administration of probiotics could significantly improve the above-mentioned parameters (p<0.05).
Conclusion: The use of probiotics could alleviate the adverse effects of stress. It could be advised to use probiotics in the form of dairy and other supplements to overcome stress.
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