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Volume 3, Issue 3 (2024)
GMJM 2024, 3(3): 93-97 |
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Received: 2024/02/15 | Accepted: 2024/07/28 | Published: 2024/09/12
Received: 2024/02/15 | Accepted: 2024/07/28 | Published: 2024/09/12
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Τsompos C, Panoulis C, Τοutouzas K, Triantafyllou A, Zografos G, Tsarea K, et al . Comparison of the Hypochloremic Effects of Erythropoietin and U-74389G. GMJM 2024; 3 (3) :93-97
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C. Τsompos *1, C. Panoulis2, K. Τοutouzas3, A. Triantafyllou4, G.C. Zografos3, K. Tsarea5, M. Karamperi5, A. Papalois6
1- Department of Gynecology, General Hospital of Thessaloniki
2- Department of Obstetrics & Gynecology, Aretaieion Hospital, Athens University, Athens, Attiki, Hellas
3- Department of Surgery, Ippokrateion General Hospital, Athens University, Athens, Attiki, Hellas
4- Department of Biologic Chemistry, Athens University, Athens, Attiki, Hellas
5- Experimental Research Centre ELPEN Pharmaceuticals, S.A. Inc., Co., Pikermi, Attiki, Hellas
6- Educational and Research Center ELPEN European University Cyprus, School of Medicine, Cyprus
2- Department of Obstetrics & Gynecology, Aretaieion Hospital, Athens University, Athens, Attiki, Hellas
3- Department of Surgery, Ippokrateion General Hospital, Athens University, Athens, Attiki, Hellas
4- Department of Biologic Chemistry, Athens University, Athens, Attiki, Hellas
5- Experimental Research Centre ELPEN Pharmaceuticals, S.A. Inc., Co., Pikermi, Attiki, Hellas
6- Educational and Research Center ELPEN European University Cyprus, School of Medicine, Cyprus
Abstract (645 Views)
Aims: This study calculated the effects on serum chloride levels after treatment with erythropoietin and the antioxidant lazaroid (U-74389G). The calculation was based on the results of 2 preliminary studies, each one of which estimated the certain influence after the respective drug usage in an induced ischemia-reperfusion animal experiment.
Materials & Methods: The 2 main experimental endpoints at which the serum chloride levels were evaluated were the 60th reperfusion min (for groups A, C, and E) and the 120th reperfusion min (for groups B, D, and F). Groups A and B were processed without drugs, C and D after the erythropoietin administration, and E and F after the antioxidant lazaroid administration.
Findings: The first preliminary study of erythropoietin presented a non-significant hypochloremic effect by 0.74+0.55% (p=0.1701). However, the second preliminary study of U-74389G showed a significant hypochloremic effect by 0.75+0.34% (p=0.031). These two studies were co-evaluated since they came from the same experimental setting. The outcome of the co-evaluation was that antioxidant lazaroid is 1.012762-fold (1.011746-1.01378) more hypochloremic than erythropoietin (p=0.0001).
Conclusion: The antioxidant capacities of U-74389G ascribe 1.012762-fold more hypochloremic effects than erythropoietin.
Materials & Methods: The 2 main experimental endpoints at which the serum chloride levels were evaluated were the 60th reperfusion min (for groups A, C, and E) and the 120th reperfusion min (for groups B, D, and F). Groups A and B were processed without drugs, C and D after the erythropoietin administration, and E and F after the antioxidant lazaroid administration.
Findings: The first preliminary study of erythropoietin presented a non-significant hypochloremic effect by 0.74+0.55% (p=0.1701). However, the second preliminary study of U-74389G showed a significant hypochloremic effect by 0.75+0.34% (p=0.031). These two studies were co-evaluated since they came from the same experimental setting. The outcome of the co-evaluation was that antioxidant lazaroid is 1.012762-fold (1.011746-1.01378) more hypochloremic than erythropoietin (p=0.0001).
Conclusion: The antioxidant capacities of U-74389G ascribe 1.012762-fold more hypochloremic effects than erythropoietin.
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