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S.e. Hashemi Feyzabadi, M. Davoodi , Z. Obeidavi ,
Volume 3, Issue 1 (Winter 2024)
Abstract
Aims: Diethylnitrosamine is a carcinogen toxin mainly found in the environment that can induce kidney injuries. Antioxidants can alleviate the adverse effects of Diethylnitrosamine on the kidney. Gamma oryzanol, as an antioxidant, seems to alleviate the adverse effects of gamma oryzanol on Diethylnitrosamine. This study was conducted for the first time to evaluate gamma oryzanol's effects on Diethylnitrosamine-induced oxidative stress in rat kidneys.
Materials & Methods: Sixty male Wistar rats were divided into four groups, including (1) negative control (lack of stress), (2) positive control (untreated rats with stress), (3 & 4) stressed rats treated with gamma oryzanol in the levels of 3000 and 6000µg/kg. The serum concentrations of creatinine and urea, lipid peroxidation, reduced glutathione level, and activities of the antioxidant enzymes, superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase were determined.
Findings: Induction of stress with Diethylnitrosamine increased the serum concentrations of creatinine and urea, and lipid peroxidation but decreased the levels of glutathione, superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase (p<0.05). The treatment with gamma oryzanol at both levels alleviated the effects of stress on lipid peroxidation and the antioxidant system (p<0.05).
Conclusion: Gamma oryzanol could decrease the adverse effects of stress on kidney parameters, and it could be advised to use gamma oryzanol to decrease stress.
F. Jazideh , E. Tarkhnishvili , S.e. Hashemi Feyzabadi,
Volume 3, Issue 2 (Spring 2024)
Abstract
Aims: Natural antimicrobial agents can decrease the risk of infection during wound healing. Olea europaea L. is an anti-inflammatory agent that can be used this way. This study was conducted for the first time to evaluate the effects of ointments prepared from olive leaf extract on inflammatory gene expressions in a mouse model's infected wound healing process.
Materials & Methods: We created two circular full-thickness wounds on the dorsal inter-scapular part of per mouse by a 5 mm biopsy punch and infected with Staphylococcus aureus and Pseudomonas aeruginosa. Following induction of infection, animals were treated with mupirocin (mupirocin group) and basal ointments containing 2.5% and 5% of the extract (2.5% & 5% OLE). A control group was also considered. We selected five mice per group, and samples were collected on days 3, 7, and 14 to investigate the total bacterial count and gene expressions.
Findings: The control group significantly showed higher wound area, total bacterial count, and higher expressions of IL-1β and TNF-α (p<0.05) and lower expressions for IL-10 and TGF-β (p<0.05). The treatment with OLE could significantly decrease wound area, total bacterial count, and expressions of IL-1β and TNF-α and increase the expression of IL-10 and TGF-β (p<0.05).
Conclusion: Ointments prepared from OLE could decrease total bacterial count, decrease the inflammatory phase, and improve wound healing.
M. Dodangheh , T. Mokhtari , S. Mojaverrostami , M. Nemati , S. Zarbakhsh, A. Arabkheradmand , Gh. Hassanzadeh,
Volume 4, Issue 1 (Winter 2025)
Abstract
Aims: Facial anthropometry is useful in individual identification and reconstructive surgery. In the present study, we aimed to determine the facial characteristic of the Iranian population through anthropometric study.
Materials & Methods: In a cross sectional study, 200 (100 male and 100 female) volunteer medical students (aged 20-25 years) of Tehran University of Medical Sciences were selected. The facial variables including total facial height, upper facial height and facial width were measured and accordingly the total facial index and upper facial index were calculated. The data were analyzed using statistical software (SPSS).
Findings: The mean age of subjects was 22.97±1.12 years. The mean total facial height, upper facial height, facial width, total facial index, and upper facial index were 11.155cm, 7.05cm, 11.68cm, 95.75 and 60.55, respectively. The most common types of face were hyperleptoprosopic (54%) and hyperleptene (54%). There were significant differences in total facial height (p<0.0001), upper facial height (p<0.0001), facial width (p=0.02), total facial index (p<0.0001), and upper facial index (p<0.0001) between males and females.
Conclusion: The most frequent face type is hyperleptoprosopic in Iranian population. Additionally, the values of facial characteristics are higher in males than females. So, sexual dimorphism was recorded according to the facial measurements of Iranian population which can be considered in the reconstructive surgeries.
E.s. Afraz, Y. Khezri, P. Ghahari, S.s. Taheri Roudsari, P. Ghahari,
Volume 4, Issue 2 (Spring 2025)
Abstract
Aims: If general practitioners are trained in oral health, it is possible to provide better guidance to patients in solving their oral and dental problems. This study aimed to assess the knowledge of general practitioners and medical students in the relationship between oral health and general health in Semnan City.
Instrument & Methods: In this cross-sectional study at Semnan University of Medical Sciences in 2021-2022, 150 internship medical students (years 6 and 7) and 50 general practitioners were selected. A checklist of demographic information and a researcher-made oral health awareness questionnaire were prepared and requested to be completed by participants.
Findings: There was no significant difference in medical students (12.62±2.57) and general practitioners (12.07±2.94) total knowledge scores (p=0.209). The “oral manifestations of systemic diseases" score in medical students (4.26±1.73) was significantly (p=0.001) higher than general practitioners (3.32±1.43). Knowledge had no significant correlation with age (p=0.263; r=-0.80) and educational history (p=0.101; r=0.131). There was no significant difference between the state of awareness of men and women (p=0.84).
Conclusion: The level of knowledge of medical students and general practitioners about oral health has no difference and is unacceptable.
M. Haghipanah , A. Safarbalou , M. Saadat , S. Rostami Mehr ,
Volume 4, Issue 3 (Summer 2025)
Abstract
Aims: It was reported that there was a significant relationship between 54G/C SREBF1 and diabetes. There may be a relation between SREBF-1 polymorphism and insulin resistance in women with PCOS, but this relation is unknown. This study investigated the relationship between SREBF-1 polymorphism and insulin resistance in polycystic ovary syndrome women.
Materials & Methods: Two hundred subjects were studied; 100 polycystic ovary syndrome subjects (case group) and 100 healthy subjects (control group). Blood samples were taken, demographic characteristics were requested, and genomic DNA was extracted. The RFLP-PCR method was used to determine the mutations of 54G/C SREBF1. Following laboratory investigation, the data were investigated using SPSS 23 software. The mutant alleles rate was determined by analysis of variance.
Findings: The genotypic frequency of GG and CC was significantly higher in patients than in the control group. In contrast, the frequency of heterozygosity was significantly higher in the control group than in the PCOS group. Allelic frequency was 78.00 for the G allele and 22.00 for the C allele in the patient group. In the healthy group, it was 75% for the G allele and 25% for the C allele. The results showed that homozygote genotypes had higher glucose and insulin resistance sensitivity.
Conclusion: The 54G/C polymorphism of SREBF-1 plays a significant role in polycystic ovary syndrome and is closely related to glucose and insulin resistance. Thus, G/C genotype frequency could be considered a biomarker for the detection of PCOS.
