en Original Research <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:"><span style="color:#7030a0">Aims:</span></span></span></span></b><span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:"> Diethylnitrosamine is a carcinogen toxin mainly found in the environment that can induce kidney injuries. Antioxidants can alleviate the adverse effects of Diethylnitrosamine on the kidney. Gamma oryzanol, as an antioxidant, seems to alleviate the adverse effects of gamma oryzanol on Diethylnitrosamine. This study was conducted for the first time to evaluate gamma oryzanol&#39;s effects on Diethylnitrosamine-induced oxidative stress in rat kidneys.</span></span></span><span style="font-size:9.0pt"><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:"><span style="color:#7030a0">Materials & Methods:</span></span></span></span></b> <span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:">Sixty male Wistar rats were divided into four groups, including (1) negative control (lack of stress), (2) positive control (untreated rats with stress), (3 & 4) stressed rats treated with gamma oryzanol in the levels of 3000 and 6000&micro;g/kg. The serum concentrations of creatinine and urea, lipid peroxidation, reduced glutathione level, and activities of the antioxidant enzymes, superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase were determined.</span></span></span><span style="font-size:9.0pt"><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:"><span style="color:#7030a0">Findings:</span></span></span></span></b><span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:"> Induction of stress with Diethylnitrosamine increased the serum concentrations of creatinine and urea, and lipid peroxidation but decreased the levels of glutathione, superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase (p<0.05). The treatment with gamma oryzanol at both levels alleviated the effects of stress on lipid peroxidation and the antioxidant system (p<0.05).</span></span></span><span style="font-size:9.0pt"><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:"><span style="color:#7030a0">Conclusion:</span></span></span></span></b> <span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:">Gamma oryzanol could decrease the adverse effects of stress on kidney parameters, and it could be advised to use gamma oryzanol to decrease stress.</span></span></span></span></span></span><br> &nbsp; Glutathione Reductase,Lipid Peroxidation,Superoxide Dismutase,Stress, 7 11 http://gmedicine.de/browse.php?a_code=A-10-1-39&slc_lang=en&sid=2 S.E. Hashemi Feyzabadi 10031947532846001332 10031947532846001332 No Semnan University of Medical Sciences, Semnan, Iran M. Davoodi 10031947532846001333 10031947532846001333 No Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran Z. Obeidavi 10031947532846001334 10031947532846001334 Yes Lorestan University of Medical Sciences, Khorramabad, Iran