en Original Research <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:"><span style="color:#7030a0">Aims: </span></span></span></span></b><span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:">Nonalcoholic fatty liver disease is a condition in which fat significantly aggregates in the liver, and the use of antioxidants can alleviate its adverse effects. This study aimed to evaluate the effects of carvone on hepatic steatosis and Nonalcoholic fatty liver disease by investigating the lipids in serum and liver.</span></span></span><span style="font-size:9.0pt"><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:"><span style="color:#7030a0">Materials & Methods:</span></span></span></span></b> <span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:">Animals were grouped into four groups and studied for 42 days, including rats fed with 1) a control diet (Control), 2) a high-fat diet (HF), 3) HF+50mg/kg body weight of carvone (50 Carv) and HF+100mg/kg body weight of carvone (100 Carv). Animals were killed, and blood and liver samples were obtained to evaluate the biochemical analyses, including triglyceride, cholesterol, nonesterified fatty acids, and thiobarbituric acid-reactive substances.</span></span></span><span style="font-size:9.0pt"><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:"><span style="color:#7030a0">Findings:</span></span></span></span></b> <span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:">Rats fed a high-fat diet showed higher levels of thiobarbituric acid-reactive substances, triglycerides, and cholesterol than the control group (p<0.05). Dietary inclusion of carvone, especially at higher levels, could reverse the effects of a high-fat diet on thiobarbituric acid-reactive substances, cholesterol, and triglycerides (p<0.05).</span></span></span><span style="font-size:9.0pt"><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:"><span style="color:#7030a0">Conclusion:</span></span></span></span></b> <span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:">Carvone can alleviate hepatic steatosis in animals with Nonalcoholic fatty liver disease. </span></span></span></span></span></span><br> &nbsp; Carvone,High fat Diet,Lipid Oxidation,Nonalcoholic Fatty Liver Disease Model, 99 102 http://gmedicine.de/browse.php?a_code=A-10-1-51&slc_lang=en&sid=2 J. Günther 10031947532846001305 10031947532846001305 No Department of Phytochemistry, Institute for Phytochemical Research (IPR), Berlin, Germany I. Schneider 10031947532846001306 10031947532846001306 No Department of Phytochemistry, Institute for Phytochemical Research (IPR), Berlin, Germany A. Krämer 10031947532846001307 10031947532846001307 Yes Department of Phytochemistry, Institute for Phytochemical Research (IPR), Berlin, Germany