en <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:"><span style="color:#7030a0">Aims:</span></span></span></span></b><span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:"> Im</span></span></span><span style="font-size:9.0pt"><span cambria="" style="font-family:">mobilization is known as a type of stress that influences antioxidant status and inflammation factors. On the other hand, probiotics could significantly improve antioxidant status and inflammatory response. This study was thus conducted to evaluate the effects of probiotics in immobilized rats by involving antioxidant and anti-inflammatory systems<span style="background:white">.</span></span></span><span style="font-size:9.0pt"><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:"><span style="color:#7030a0">Materials & Methods:</span></span></span></span></b><span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:"> A</span></span></span><span style="font-size:9.0pt"><span cambria="" style="font-family:"> total number of 72 Albino Wistar rats were divided into 3 groups, including a normal control group without stress (Control), 2) Immobilized rats without additive (Immobilized), and 3) Immobilized rats given with 104 CFU probiotics.day-1(Probiotic). Inflammatory and pro-inflammatory cytokines, corticosterone, and serum antioxidants were evaluated on days 7 and 14<span style="background:white">.</span></span></span><span style="font-size:9.0pt"><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:"><span style="color:#7030a0">Findings:</span></span></span></span></b> <span style="font-size:9.0pt"><span cambria="" style="font-family:">Results showed that immobilization could significantly increase the serum concentrations of TNF-&alpha;, TGF-&beta; corticosterone, MDA, and NO and also decrease SOD, GPx, and IL-10 in days 7 and 14, as immobilized rats were compared with control rats (p<0.05). However, administration of probiotics could significantly improve the above-mentioned parameters (p<0.05)<span style="background:white">.</span></span></span><span style="font-size:9.0pt"><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:"><span style="color:#7030a0">Conclusion:</span></span></span></span></b> <span style="font-size:9.0pt"><span cambria="" style="font-family:">The use of probiotics could alleviate the adverse effects of stress. It could be advised to use probiotics in the form of dairy and other supplements to overcome stress<span style="background:white">.</span></span></span></span></span></span><br> &nbsp; Antioxidant Status,Immobilization Stress,Inflammatory Responses, 133 137 http://gmedicine.de/browse.php?a_code=A-10-1-58&slc_lang=en&sid=2 A. Bakhtiari 10031947532846001278 10031947532846001278 No Department of Internal Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran S. Aboudzadeh 10031947532846001279 10031947532846001279 No Imam Ali Health Center, Abadan University of Medical Sciences, Abadan, Iran S. Vaziri 10031947532846001280 10031947532846001280 No Student Research Committee, Hormozgan University of Medical Sciences, Bandar Abbas, Iran M. Mirzaei Roozbahani 10031947532846001281 10031947532846001281 Yes Department of General Surgery, Lorestan University of medical Sciences, Khorramabad, Iran