en Original Research <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:"><span style="color:#7030a0">Aims:</span></span></span></span></b> <span style="font-size:9.0pt"><span cambria="" style="font-family:">Obesity and inflammation, which result from obesity, affect fertility and the male reproductive system by negatively affecting erectile dysfunction and semen variables. Novel factors could be used to determine fertility and infertility. This study was conducted to evaluate the relation between novel markers and sperm quality in obese rats.</span></span><span style="font-size:9.0pt"><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:"><span style="color:#7030a0">Materials & Methods:</span></span></span></span></b> <span style="font-size:9.0pt"><span cambria="" style="font-family:">The animals were divided into two groups. One group received a normal rat pellet diet for 12 weeks of intervention, while the other received a high-fat diet. The serum concentrations of IL-1&beta;, IL-6, IL-3, TNF-&alpha;, sialic acid, CRP, haptoglobin, and fibrinogen were measured. Sperm motility was assessed<span style="background:white">.</span></span></span><span style="font-size:9.0pt"><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:"><span style="color:#7030a0">Findings:</span></span></span></span></b> <span style="font-size:9.0pt"><span cambria="" style="font-family:">Progressive motility, non-progressive motility, and immotile were respectively lower and higher in obese rats compared to control groups (P<0.05). It was observed that there was a positive correlation between inflammatory factors and immobility and a negative correlation between progressive motility and inflammation (P<0.05).</span></span><span style="font-size:9.0pt"><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="background:white"><span cambria="" style="font-family:"><span style="color:#7030a0">Conclusion:</span></span></span></span></b> <span style="font-size:9.0pt"><span cambria="" style="font-family:">Pro-inflammatory factors have a significant correlation with sperm quality and could be used as markers for infertility<span style="background:white">.</span></span></span></span></span></span> Fibrinogen,Inflammatory Factors,Obese Rats,Sialic Acid, 127 131 http://gmedicine.de/browse.php?a_code=A-10-1-60&slc_lang=en&sid=2 A. Kheirollahi 10031947532846001275 10031947532846001275 No Lorestan University of Medical Sciences, Khorramabad, Iran Sh. Hatami 10031947532846001276 10031947532846001276 No Lorestan University of Medical Sciences, Khorramabad, Iran A.I. Olfat 10031947532846001277 10031947532846001277 Yes Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, China