en <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span cambria="" style="font-family:"><span style="color:#7030a0">Aims:</span></span></span></b> <span style="font-size:9.0pt"><span cambria="" style="font-family:">Carbon tetrachloride (CCl4) has been applied to induce the toxicity and hepatic fibrosis. Natural antioxidants are known as efficient and safe treatments for hepatotoxicity compared with synthetic antioxidants. This study aimed to evaluate the effects of oral administration of pulegone in carbon tetrachloride-induced oxidative stress in Wistar rats.</span></span><span style="font-size:9.0pt"><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span cambria="" style="font-family:"><span style="color:#7030a0">Materials & Methods:</span></span></span></b><span style="font-size:9.0pt"><span cambria="" style="font-family:"> Twenty rats were randomly assigned into four groups including control animals that received olive oil, Toxic control that administrated with 30% CCl4, Pulegone-20 & 30 that administrated with pulegone 20mg/kg and 30mg/kg, respectively, with in along to 30% CCl4. The liver levels of total cholesterol, triacylglycerides, phospholipids, superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GPx), and vitamins C and E were evaluated.</span></span><span style="font-size:9.0pt"><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span cambria="" style="font-family:"><span style="color:#7030a0">Findings:</span></span></span></b> <span style="font-size:9.0pt"><span cambria="" style="font-family:">Administration of CCl4 increased levels of cholesterol, triacylglycerides and lipid oxidation, but it also reduced levels of phospholipids, SOD, CAT, GSH, GPx, and vitamins C and E (p<0.05). Oral administration of pulegone, especially in the higher levels, could reverse negative effects of CCl4 (p<0.05).</span></span><span style="font-size:9.0pt"><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span cambria="" style="font-family:"><span style="color:#7030a0">Conclusion:</span></span></span></b><span style="font-size:9.0pt"><span cambria="" style="font-family:"> Using pulegone is recommended for liver protection due to its vital therapeutic antioxidant properties.</span></span></span></span></span> Models, Animal,Enzymatic Antioxidants,Liver Cholesterol,Vitamin C, 7 11 http://gmedicine.de/browse.php?a_code=A-10-1-66&slc_lang=en&sid=2 A. Rabinovich 10031947532846001241 10031947532846001241 No Pirogov Russian National Research Medical University, Moscow, Russia N. Romanoff 10031947532846001242 10031947532846001242 Yes Pirogov Russian National Research Medical University, Moscow, Russia D. Mordvinov 10031947532846001243 10031947532846001243 No Institute for Biomedical Research, Association of Pharmaceutical Research and Development, Kyiv, Ukraine M. Ivanov 10031947532846001244 10031947532846001244 No Institute for Biomedical Research, Association of Pharmaceutical Research and Development, Kyiv, Ukraine