en <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span cambria="" style="font-family:"><span style="color:#7030a0">Aims:</span></span></span></b> <span style="font-size:9.0pt"><span cambria="" style="font-family:">Natural agents have been used for protection against damages. This study was conducted to evaluate the effects of dietary supplementing of resveratrol improves on antioxidant status improvement in hypercholestrolemic rats.</span></span><span style="font-size:9.0pt"><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span cambria="" style="font-family:"><span style="color:#7030a0">Materials & Methods:</span></span></span></b> <span style="font-size:9.0pt"><span cambria="" style="font-family:">Rats were divided into 6 groups including rats fed with basal diet (Control group), basal diet containing resveratrol 2.5mg/kg (2.5 RES), basal diet containing 5.0mg/kg of resveratrol (5.0 RES), basal diet containing 1% cholesterol + 0.5% cholic acid (Control HC), basal diet containing 2.5mg/kg of resveratrol and 1% cholesterol + 0.5% cholic acid&nbsp; (2.5 RES-HC), basal diet containing resveratrol 5.0mg/kg and 1% cholesterol + 0.5% cholic acid&nbsp; (5.0 RES-HC). The plasma levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), malondialdehyde (MDA), and low density lipoprotein (LDL) and expression levels of glutathione peroxidase (GPx), glutathione reductase (GR), paraoxonase-1 and sulfiredoxin-1 were assessed.</span></span><span style="font-size:9.0pt"><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span cambria="" style="font-family:"><span style="color:#7030a0">Findings:</span></span></span></b><span style="font-size:9.0pt"><span cambria="" style="font-family:"> The plasma concentrations of cholesterol, triglycerides, LDL-C and malondialdehyde were significantly higher and level of HDL was significantly lower in hypercholesterolemic rats, but dietary supplementation resveratrol significantly improved them (p<0.05). Hypercholesterolemic rats showed a decrease in GPx and GR and an increase in paraoxonase-1 and sulfiredoxin-1 compared to the healthy control (p<0.05), but applying resveratrol improved the adverse effects of hypercholesterolemia on mentioned parameters (p<0.05).</span></span><span style="font-size:9.0pt"><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span cambria="" style="font-family:"><span style="color:#7030a0">Conclusion:</span></span></span></b><span style="font-size:9.0pt"><span cambria="" style="font-family:"> Resveratrol can be used for treatment of patients with hypercholesterolemia.</span></span></span></span></span> Antioxidant Status,Blood Parameters,Resveratrol,Rats, Wistar, 25 29 http://gmedicine.de/browse.php?a_code=A-10-1-69&slc_lang=en&sid=2 S. Yousefi 10031947532846001256 10031947532846001256 No Department of Biochemistry, Faculty of Medicine, Semnan University of Medical Science, Semnan, Iran F. Nemati Karimooy 10031947532846001257 10031947532846001257 No Medical School, Mashhad University of Medical Sciences, Mashhad, Iran T. Miyanbandi 10031947532846001258 10031947532846001258 No School of Nursing & Midwifery, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran F. Esmaeilpour 10031947532846001259 10031947532846001259 Yes Georgian Center for Neuroscience Research, International Center for Intelligent Research, Tbilisi, Georgia