en <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span cambria="" style="font-family:"><span style="color:#7030a0">Aims:</span></span></span></b> <span style="font-size:9.0pt"><span cambria="" style="font-family:">Polycystic ovary syndrome is one of the most common endocrine disorders in the women and animals. Some common hormonal therapies are used to treat the PCOS condition. This study was conducted to evaluate the effects of curcumin on rats with PCOS by evaluation of the gene expression of the GLUT4 and Er&alpha; and insulin resistance.</span></span><span style="font-size:9.0pt"><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span cambria="" style="font-family:"><span style="color:#7030a0">Materials & Methods:</span></span></span></b> <span style="font-size:9.0pt"><span cambria="" style="font-family:">Following induction of PCOS, sixty Sprague&ndash;Dawley female rats were divided into four groups including: (1) Control group (2) Control PCOS (3 & 4) those treated with 100 and 200 mg/kg of curcumin respectively. Body weight, fasting blood glucose (FBG), fasting insulin serum (FIS), homeostasis model assessment of insulin resistance (HOMA-IR) and gene expression of GLUT4 and Er&alpha; were evaluated.</span></span><span style="font-size:9.0pt"><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span cambria="" style="font-family:"><span style="color:#7030a0">Findings:</span></span></span></b><span style="font-size:9.0pt"><span cambria="" style="font-family:"> Induction of PCOS increased body weight, FBG, FIS, HOMA-IR and decreased gene expression of GLUT4 and Er&alpha; (p<0.05), but oral administration of curcumin could alleviate adverse effects of PCOS on the mentioned parameters (p<0.05).</span></span><span style="font-size:9.0pt"><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span cambria="" style="font-family:"><span style="color:#7030a0">Conclusion:</span></span></span></b><span style="font-size:9.0pt"><span cambria="" style="font-family:"> Curcumin alleviates adverse effects of polycystic ovary syndrome. <span style="background:white"></span></span></span></span></span></span><br> &nbsp; Curcumin,Polycystic Ovary Syndrome,Erα,Fasting Insulin,GLUT4,Rats, 31 35 http://gmedicine.de/browse.php?a_code=A-10-1-70&slc_lang=en&sid=2 G. Dzigandzli 10031947532846001260 10031947532846001260 Yes Georgian Center for Neuroscience Research, International Center for Intelligent Research, Tbilisi, Georgia M. Askaripour 10031947532846001261 10031947532846001261 No Department of Physiology, School of Medicine, Bam University of Medical Sciences, Bam, Iran S. Rajabi 10031947532846001262 10031947532846001262 No Department of Physiology, School of Medicine, Bam University of Medical Sciences, Bam, Iran M.K. Shahmoradi 10031947532846001263 10031947532846001263 No Department of General Surgery, Lorestan University of Medical Sciences, Khorramabad, Iran