en <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="background:white"><span cambria="" style="font-family:"><span style="color:#7030a0">Aims:</span></span></span></b><b> </b><span cambria="" style="font-family:">Polycystic ovarian syndrome has been related to dyslipidemia and suppression of antioxidant status. However, novel agents such as menthol can be an efficient strategy for alleviation of this syndrome. This study was conducted to evaluate the effects of different levels of menthol on blood biochemical parameters and antioxidant status in polycystic ovarian syndrome-induced Wistar rats.</span><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="background:white"><span cambria="" style="font-family:"><span style="color:#7030a0">Materials & Methods:</span></span></span></b> <span cambria="" style="font-family:">In this experimental study, 50 Wistar rats were used in 5 groups; healthy (negative control), polycystic ovarian syndrome that did not receive any menthol (positive control), and polycystic ovarian syndrome that received 2- (PCOS-2), 4- (PCOS-4) and 6mg/kg of body weight of menthol (PCOS-6). To induce the polycystic ovarian syndrome, 5mg of estradiol valerate was administrated. At the end of the trial session, blood samples were taken to evaluate plasma concentrations of glucose, insulin, total cholesterol, triglycerides, HDL-C, LDL-C, ferric-reducing ability of plasma (FRAP), advanced oxidation protein product (AOPP) and total oxidation status (TOS).</span><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="background:white"><span cambria="" style="font-family:"><span style="color:#7030a0">Findings:</span></span></span></b> <span cambria="" style="font-family:">Induction of polycystic ovarian syndrome increased glucose, insulin, total cholesterol, triglycerides, LDL-C, FRAP, AOPP and TOS, and decrease HDL-C. The use of menthol especially in higher levels improved the mentioned parameters. Polycystic ovarian syndrome also increased body weight and oral treatment of menthol helped to maintain the body weight.</span><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span cambria="" style="font-family:"><span style="color:#7030a0">Conclusion:</span></span></b> <span cambria="" style="font-family:">Menthol improves antioxidant status in rats with polycystic ovarian syndrome. Thus, use of menthol is recommended for treatment of polycystic ovarian syndrome.</span></span></span></span> Glucose,Lipid Profile,Oxidation,Polycystic Ovarian Syndrome,Rats, 47 51 http://gmedicine.de/browse.php?a_code=A-10-1-73&slc_lang=en&sid=2 B. Mesbahzadeh 10031947532846001211 10031947532846001211 No Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran M. Garmsiri 10031947532846001212 10031947532846001212 No Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran F. Jalalvand 10031947532846001213 10031947532846001213 No Department of General Surgery, Lorestan University of Medical Sciences, Khorramabad, Iran L. Shojaie 10031947532846001214 10031947532846001214 No Tehran University of Medical Sciences, Tehran, Iran M.A. Kakar 10031947532846001215 10031947532846001215 Yes L&DD Department, Spinny Road Quetta, Balochistan, Pakistan