en Original Research <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="background:white"><span cambria="" style="font-family:"><span style="color:#7030a0">Aims:</span></span></span></b> <span cambria="" style="font-family:">It has been reported that ginger is involved in serotonergic system. It seems that ginger effect could be attributed to its active compound or gingerol. The present study was conducted to evaluate the effects of gingerol on antidepressant-like effects by investigation of serotonergic system in mice mode<span style="background:white">l.</span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="background:white"><span cambria="" style="font-family:"><span style="color:#7030a0">Materials & Methods:</span></span></span></b> <span cambria="" style="font-family:">In an experimental design, following pilot study and selection of doses, mice were divided into 4 groups. Receptor antagonists were injected, gingerol was administrated and a trial suspension test was conducted<span style="background:white">.</span></span><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="background:white"><span cambria="" style="font-family:"><span style="color:#7030a0">Findings:</span></span></span></b> <span cambria="" style="font-family:">Gingerol could induce antidepressant-like effect (p<0.001), without induction of changes in spontaneous locomotor activity in the open-field test. Pretreatment of mice with pCPA (preventor of serotonin synthesis), WAY100135 (receptor antagonist), ketanserin (5HT2A receptor antagonist), and cyproheptadine (5HT2 receptor antagonist) prevented the antidepressant-like effect induced by the gingerol (p<0.05).</span><span style="background:white"><span style="font-family:"Cambria",serif"></span></span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="background:white"><span cambria="" style="font-family:"><span style="color:#7030a0">Conclusion:</span></span></span></b> <span cambria="" style="font-family:">Gingerol is involved in antidepressant-like effects through serotonergic system in mice model. <span style="background:white"></span></span></span></span></span><br> &nbsp; Antidepressant-like,Gingerol,Mouse Model,Serotonin Pathway, 59 63 http://gmedicine.de/browse.php?a_code=A-10-1-76&slc_lang=en&sid=2 S. Sedighi 10031947532846001219 10031947532846001219 No Tehran Medical Branch, Islamic Azad University, Tehran, Iran B. Nasiri 10031947532846001220 10031947532846001220 No Lorestan University of Medical Sciences, Khorramabad, Iran R. Alipoor 10031947532846001221 10031947532846001221 No Hormozgan University of Medical Sciences, Bandar Abbas, Iran N. MoradiKor 10031947532846001222 10031947532846001222 Yes International Center for Neuroscience Research, Institute for Intelligent Research, Tbilisi, Georgia