en Systematical Review/Meta-Analysis <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span cambria="" style="font-family:"><span style="color:#7030a0">Aims:</span></span></span></b><i> </i><span style="font-size:10.0pt"><span cambria="" style="font-family:">There are treatments that seem to help maintain mental skills and reduce the effects of Alzheimer&#39;s disease. On the other hand, physical exercises can have a protective effect against deterioration. The level of BDNF decreases in AD, and the decrease in this factor is consistent with the decrease in hippocampal volume in this disease. This study aimed to evaluate the effects of exercises on Brain-Derived Neurotrophic Factor levels in patients with Alzheimer&#39;s.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span cambria="" style="font-family:"><span style="color:#7030a0">Information & Methods: </span></span></span></b><span style="font-size:10.0pt"><span cambria="" style="font-family:">This study was conducted based on the PRISMA guidelines in 2023. English papers on the effects of exercises on BDNF levels in subjects with Alzheimer&#39;s were included. Unpublished papers, review papers, and studies with deficient information were not included. </span></span><span style="font-size:10.0pt"><span cambria="" style="font-family:">Keywords were searched in PubMed, Scopus, EuropePMC, Cochrane Central Database, Embase, and Web of Science databases. All the studies were managed with Endnote&trade; X9.2 software. </span></span>&nbsp;</span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span cambria="" style="font-family:"><span style="color:#7030a0">Findings: </span></span></span></b><span style="font-size:10.0pt"><span cambria="" style="font-family:">Twelve papers were reviewed, comprising 4 human and 8 animal studies. The periods for human studies lasted 26 to 52 weeks. Animal studies lasted 4 to 13 weeks. The samples were collected from plasma in human studies, while most animal studies were conducted on the expression of BDNF in the hippocampus (n=6). Out of 12 papers, 3 human papers and 8 animal studies showed that exercises significantly increased the concentration of the expression of BDNF </span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span cambria="" style="font-family:"><span style="color:#7030a0">Conclusion:</span></span></span></b><span style="font-size:10.0pt"><span cambria="" style="font-family:"> Exercise positively improves and increases the expression and concentrations of </span></span><span style="font-size:10.0pt"><span cambria="" style="font-family:">Brain-Derived Neurotrophic Factor</span></span><span style="font-size:10.0pt"><span cambria="" style="font-family:">. &nbsp;</span></span></span></span></span><br> &nbsp; Alzheimer,Brain-Derived Neurotrophic Factor,Exercise, 71 75 http://gmedicine.de/browse.php?a_code=A-10-255-1&slc_lang=en&sid=2 S. Rostami Mehr 10031947532846001228 10031947532846001228 No Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran R. Hossein Gholizadeh Salmani 10031947532846001229 10031947532846001229 No Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran S. Abbasi-Maleki 10031947532846001230 10031947532846001230 No Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran S. Rasheed 10031947532846001231 10031947532846001231 No Department of Medicine Emergency, Acharya Shree Bhikshu Hospital, Moti Nagar, New Delhi, India M. Haghipanah 10031947532846001232 10031947532846001232 Yes International Center for Neuroscience Research, Institute for Intelligent Research, Tbilisi, Georgia