fa Original Research <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span cambria="" style="font-family:"><span style="color:#7030a0">Aims:</span></span></span></b><span style="font-size:10.0pt"><span cambria="" style="font-family:"> Spinal anesthesia-induced hypotension is a major challenge during cesarean sections under spinal anesthesia. Ondansetron may be a good option for solving this complication. This study aimed to evaluate the effect of ondansetron in preventing spinal anesthesia-induced hypotension in pregnant women undergoing elective cesarean section.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span cambria="" style="font-family:"><span style="color:#7030a0">Materials & Methods:</span></span></span></b><span style="font-size:10.0pt"><span cambria="" style="font-family:"> This prospective clinical trial was conducted in 2023 with 120 pregnant women classified as ASA I or II. The women were divided into two groups: One group received 4mg of ondansetron diluted in 10ml saline, and the second group received 10ml of normal saline. Different parameters, including systolic and diastolic blood pressure, heart rate, and SpO₂, were recorded at multiple time intervals. The incidence of nausea, vomiting, and shivering was also assessed. </span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span cambria="" style="font-family:"><span style="color:#7030a0">Findings:</span></span></span></b> <span style="font-size:10.0pt"><span cambria="" style="font-family:">The ondansetron group showed a significant reduction in systolic and diastolic blood pressure compared to the saline group at several intervals immediately following the block. The results did not show differences in heart rate between the two groups, except during recovery, when the normal saline group had a higher heart rate. The incidence of nausea and shivering was similar between groups, while vomiting was slightly less frequent in the ondansetron group; the difference was not statistically significant.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span cambria="" style="font-family:"><span style="color:#7030a0">Conclusion:</span></span></span></b> <span style="font-size:10.0pt"><span cambria="" style="font-family:">Ondansetron may temporarily reduce blood pressure following spinal anesthesia in pregnant women undergoing cesarean section. Further studies are needed to determine its role in preventing hypotension during spinal anesthesia and to explore its potential effects on other perioperative parameters.</span></span></span></span></span> Ondansetron , Hypotension , Blood Pressure , Pregnant Women , Anesthesia 103 109 http://gmedicine.de/browse.php?a_code=A-10-284-1&slc_lang=fa&sid=2 S.A. Hoseinikhah 10031947532846001203 10031947532846001203 Yes Department of Anesthesiology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran S. Pazooki 10031947532846001204 10031947532846001204 No Department of Anesthesiology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran H. Jarineshin 10031947532846001205 10031947532846001205 No Department of Anesthesiology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran F. Fekrat 10031947532846001206 10031947532846001206 No Department of Anesthesiology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran