Volume 3, Issue 3 (2024)                   GMJM 2024, 3(3): 1001-1007 | Back to browse issues page
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Haghipanah M, Etekochay M, Saadat M, Safarbalou A. The Relationship Between SREBF-1 Polymorphism with Insulin Resistance in Women Polycystic Ovary Syndrome. GMJM 2024; 3 (3) :1001-1007
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1- International Center for Neuroscience Research, Institute for Intelligent Research, Tbilisi, Georgia
2- PinnacleCare International, Baltimore, Maryland
3- Department of Anatomical Sciences, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
4- Mazandaran University of Medical Sciences, Sari, Iran
Abstract   (132 Views)
It was reported a significant relation between 54G/C SREBF1 with diabetes. It may be a relation between SREBF-1 polymorphism with insulin resistant in women PCOS but this relation is unknown. This study was conducted to investigate the relationship between SREBF-1 polymorphism with insulin resistant in women polycystic ovary syndrome. In this study, 200 subjects were studied including 100 PCOS subjects (Case group) and 100 healthy subjects (control group). Blood samples were taken, demographic characteristics were requested and genomic DNA was extracted. To determine the mutations of 54G/C SREBF1, RFLP-PCR method was used. Following laboratory investigation, the data were investigated in SPSS software. The mutant frequency and its rate were determined by using SPSS software. The mutant allels rate was determined by analysis of variance. The genotypic frequency of GG and CC was significantly higher in patients than in the control group, while the frequency of heterozygosity was significantly higher in the control group than in the PCOS group. Allelic frequency was 78.00 for G allele and 22.00 for C allele in the patient group. In the healthy group, it was 75% for G allele and 25% for C allele.  The results showed that homozygote genotypes had higher sensitivity for higher glucose and insulin resistant. In conclusion, 54G/C polymorphism of SREBF-1 had significant role in PCOS and also a closed relation with glucose and insulin resistant. It could be stated that G/C genotype frequency could be considered as biomarker for detection of PCOS.
 
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