Volume 1, Issue 3 (2022)                   GMJM 2022, 1(3): 77-80 | Back to browse issues page
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Mahdavi F, Azhough R. Effectiveness of Metronidazole Ointment on the Pain of Hemorrhoidectomy Patients. GMJM 2022; 1 (3) :77-80
URL: http://gmedicine.de/article-2-201-en.html
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1- Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
* Corresponding Author Address: Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. (r_azhough@yahoo.com)
Abstract   (343 Views)
Aims: Recently, the use of metronidazole in reducing pain after hemorrhoids has been considered and it has been shown that the oral form of this drug can significantly reduce pain after hemorrhoidectomy; However, other studies have not confirmed the effect of oral metronidazole in reducing pain. The use of oral form has limitations compared to the local form due to its general effects. Therefore, in this study, the benefits of using metronidazole topical form in pain control after hemorrhoidectomy were evaluated.
Instrument & Methods: This descriptive cross-sectional study was performed in 2019 with the participation of 94 hemorrhoidectomy patients in Imam Reza Hospital (Tabriz Medical Sciences); For half of the participants, metronidazole topical ointment was administered three times daily and for the other group, placebo ointment was administered. Patients' pain intensity was measured using a VAS questionnaire and compared between the two groups.
Findings: Intensity in the first hours after surgery as well as the first two weeks after surgery (measured daily) in the group receiving topical metronidazole was significantly lower than in the placebo group; The dose of acetaminophen codeine in the placebo group up to day 14 was significantly higher than the group receiving metronidazole.
Conclusion: Topical metronidazole can reduce postoperative pain. In addition, the pain after defecation and the need for analgesia are significantly reduced. However, further studies are needed for the widespread use of this form of medicine in the clinic.
 
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