Volume 1, Issue 3 (2022)                   GMJM 2022, 1(3): 91-95 | Back to browse issues page
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Analytical Review |



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Saboktakin L. Obesity and its Association with Childhood Diabetes; an Analytic Review. GMJM 2022; 1 (3) :91-95
URL: http://gmedicine.de/article-2-205-en.html
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Authors L. Saboktakin *
“Tuberculosis and Lung Disease Research Center” and “Department of Otorhinolaryngology”, Tabriz University of medical Sciences, Tabriz, Iran
* Corresponding Author Address: Department of Otorhinolaryngology, Tabriz University of Medical Sciences, Tabriz, Iran. (lida_saboktanin@gmail.com)
Abstract   (330 Views)
Introduction: Incidence of diabetes in children, causes and risk factors for this complication, types of diabetes in children, the need to follow the recommendations, management and control of type 1 diabetes and nutritional tips to control diabetes in children, we will report. Type 1 diabetes is more common in children and type 2 diabetes is more likely to occur in adults, especially after the age of 40. Although type 1 diabetes accounts for only five to 10 percent of all cases of diabetes, it is the most common type of diabetes in children. In fact, 85% of the most recently diagnosed types of diabetes are in children and young people under 18 And for this reason, it is also called juvenile diabetes.
Conclusion: Obesity is a major cause of diabetes in children. In this study, based on the available scientific evidence, the relationship between obesity and diabetes in children and its mechanism and pathophysiology are accurately stated.

1. Larkins NG, Teixeira-Pinto A, Craig JC. The prevalence and predictors of hypertension in a National Survey of Australian Children. Blood Press. 2018;27(1):41-7. [Link] [DOI:10.1080/08037051.2017.1380502]
2. Lalan S, Jiang S, Ng DK, Kupferman F, Warady BA, Furth S, et al. Cardiometabolic risk factors, metabolic syndrome, and chronic kidney disease progression in children. J Pediatr. 2018;202:163-70. [Link] [DOI:10.1016/j.jpeds.2018.06.007]
3. Ladhani M, Lade S, Alexander SI, Baur LA, Clayton PA, McDonald S, Craig, et al. Obesity in pediatric kidney transplant recipients and the risks of acute rejection, graft loss and death. Pediatr Nephrol. 2017;32(8):1443-50. [Link] [DOI:10.1007/s00467-017-3636-1]
4. Clark SL, Denburg MR, Furth SL. Physical activity and screen time in adolescents in the chronic kidney disease in children (CKiD) cohort. Pediatr Nephrol. 2016;31(5):801-8. [Link] [DOI:10.1007/s00467-015-3287-z]
5. Brady TM. The role of obesity in the development of left ventricular hypertrophy among children and adolescents. Curr Hypertens Rep. 2016;18(1):3. [Link] [DOI:10.1007/s11906-015-0608-3]
6. Brady TM, Roem J, Cox C, Schneider MF, Wilson AC, Furth SL, et al. Adiposity, sex, and cardiovascular disease risk in children with CKD: a longitudinal study of youth enrolled in the Chronic Kidney Disease in Children (CKiD) study. Am J Kidney Dis. 2020;76(2):166-73. [Link] [DOI:10.1053/j.ajkd.2020.01.011]
7. Shayganmehr A, Dorosti AA, Saboktakin L, Abbasi M, Khaiatzadeh S, Khoshmaram N, et al. Clinical pediatric screening for COVID-19. Iran J Pediatr. 2021;31(1):e107780. [Link] [DOI:10.5812/ijp.107780]
8. Kalantar-Zadeh K, Rhee CM, Chou J, Ahmadi SF, Park J, et al. The obesity paradox in kidney disease: how to reconcile it with obesity management. Kidney Int Rep. 2017;2(2):271-81. [Link] [DOI:10.1016/j.ekir.2017.01.009]
9. Kim S, Macaskill P, Hodson EM, Daylight J, Williams R, Kearns R. Beginning the trajectory to ESKD in adult life: albuminuria in Australian aboriginal children and adolescents. Pediatr Nephrol. 2017;32(1):119-29. [Link] [DOI:10.1007/s00467-016-3429-y]
10. Byun HJ, Ha JY, Jung W, Kim BH, Park CH, Kim CI. The impact of obesity on febrile urinary tract infection and renal scarring in children with vesicoureteral reflux. J Pediatr Urol. 2017;13(1):67.e1-6. [Link] [DOI:10.1016/j.jpurol.2016.08.018]
11. Nowak KL, You Z, Gitomer B, Brosnahan G, Torres VE, Chapman AB, Perrone RD, et al. Overweight and obesity are predictors of progression in early autosomal dominant polycystic kidney disease. J Am Soc Nephrol. 2018;29(2):571-8. [Link] [DOI:10.1681/ASN.2017070819]
12. Chagnac A, Zingerman B, Rozen-Zvi B, Herman-Edelstein M. Consequences of glomerular hyperfiltration: The role of physical forces in the pathogenesis of chronic kidney disease in diabetes and obesity. Nephron. 2019;143(1):38-42. [Link] [DOI:10.1159/000499486]
13. Yang S, Cao C, Deng T, Zhou Z. Obesity-related glomerulopathy: A latent change in obesity requiring more attention. Kidney Blood Press Res. 2020;45(4):510-22. [Link] [DOI:10.1159/000507784]
14. Winnicki E, Dharmar M, Tancredi DJ, Nguyen S, Butani L. Effect of BMI on allograft function and survival in pediatric renal transplant recipients. Pediatr Nephrol. 2018;33(8):1429-35. [Link] [DOI:10.1007/s00467-018-3942-2]
15. Saboktakin L, Bilan N, Ghalehgolab Behbahan A, Poorebrahim S. Relationship between resistin levels and sepsis among children under 12 years of age: A case control study. Front Pediatr. 2019;7:355. [Link] [DOI:10.3389/fped.2019.00355]
16. Nehus EJ, Khoury JC, Inge TH, Xiao N, Jenkins TM, Moxey-Mims MM, et al. Kidney outcomes three years after bariatric surgery in severely obese adolescents. Kidney Int. 2017;91(2):451-8. [Link] [DOI:10.1016/j.kint.2016.09.031]
17. Colquitt JL, Loveman E, O'Malley C, Azevedo LB, Mead E, Al-Khudairy L, et al. Diet, physical activity, and behavioural interventions for the treatment of overweight or obesity in preschool children up to the age of 6 years. Cochrane Database Syst Rev. 2016;3(3):CD012105. [Link] [DOI:10.1002/14651858.CD012105]
18. Mead E, Brown T, Rees K, Azevedo LB, Whittaker V, Jones D, et al. Diet, physical activity and behavioural interventions for the treatment of overweight or obese children from the age of 6 to 11 years. Cochrane Database Syst Rev. 2017;6(6):CD012651. [Link] [DOI:10.1002/14651858.CD012651]
19. Al-Khudairy L, Loveman E, Colquitt JL, Mead E, Johnson RE, Fraser H, et al. Diet, physical activity and behavioural interventions for the treatment of overweight or obese adolescents aged 12 to 17 years. Cochrane Database Syst Rev. 2017;6(6):CD012691. [Link] [DOI:10.1002/14651858.CD012691]
20. Shoemaker AA, Chung ST, Fleischman A. Trends in pediatric obesity management, a survey from the Pediatric Endocrine Society Obesity Committee. J Pediatr Endocrinol Metab. 2020;33(4):469-72. [Link] [DOI:10.1515/jpem-2019-0546]
21. Rafeey M, Saboktakin L, Hasani JS, Naghashi S. Diagnostic value of anti-smooth muscle antibodies and liver enzymes in differentiation of extrahepatic biliary atresia and idiopathic neonatal hepatitis. Afr J paediatr Surg: AJPS. 2016;13(2):63-8. [Link] [DOI:10.4103/0189-6725.182558]
22. Masarwa R, Brunetti VC, Aloe S, Henderson M, Platt RW, Filion KB. Efficacy and safety of metformin for obesity: A systematic review. Pediatrics. 2021;147(3):e20201610. [Link] [DOI:10.1542/peds.2020-1610]
23. Bjornstad P, Schäfer M, Truong U, Cree-Green M, Pyle L, Baumgartner A, et al. Metformin improves insulin sensitivity and vascular health in youth with type 1 diabetes mellitus: randomized controlled trial. Circulation, 2018;138(25):2895-907. [Link] [DOI:10.1161/CIRCULATIONAHA.118.035525]
24. Kwon S, Kim YC, Park JY, Lee J, An JN, Kim CT, et al. The long-term effects of metformin on patients with type 2 diabetic kidney disease. Diabetes Care. 2020;43(5):948-55. [Link] [DOI:10.2337/dc19-0936]
25. Chen W, Ducharme-Smith K, Davis L, Hui WF, Warady BA, Furth SL, et al. Dietary sources of energy and nutrient intake among children and adolescents with chronic kidney disease. Pediatr Nephrol. 2017;32(7):1233-41. [Link] [DOI:10.1007/s00467-017-3580-0]
26. Weaver Jr DJ, Selewski D, Janjua H, Iorember F. Improved cardiovascular risk factors in pediatric renal transplant recipients on steroid avoidance immunosuppression: A study of the Midwest Pediatric Nephrology Consortium. Pediatr Transplant. 2016;20(1):59-67. [Link] [DOI:10.1111/petr.12633]