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Volume 3, Issue 3 (2024)
GMJM 2024, 3(3): 99-102 |
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Received: 2024/01/16 | Accepted: 2024/06/5 | Published: 2024/07/11
Received: 2024/01/16 | Accepted: 2024/06/5 | Published: 2024/07/11
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Günther J, Schneider I, Krämer A. Carvone Prevents and Alleviates Hepatic Steatosis in Rat Model with Nonalcoholic Fatty Liver Disease. GMJM 2024; 3 (3) :99-102
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Carvone Prevents and Alleviates Hepatic Steatosis in Rat Model with Nonalcoholic Fatty Liver Disease
1- Department of Phytochemistry, Institute for Phytochemical Research (IPR), Berlin, Germany
Abstract (556 Views)
Aims: Nonalcoholic fatty liver disease is a condition in which fat significantly aggregates in the liver, and the use of antioxidants can alleviate its adverse effects. This study aimed to evaluate the effects of carvone on hepatic steatosis and Nonalcoholic fatty liver disease by investigating the lipids in serum and liver.
Materials & Methods: Animals were grouped into four groups and studied for 42 days, including rats fed with 1) a control diet (Control), 2) a high-fat diet (HF), 3) HF+50mg/kg body weight of carvone (50 Carv) and HF+100mg/kg body weight of carvone (100 Carv). Animals were killed, and blood and liver samples were obtained to evaluate the biochemical analyses, including triglyceride, cholesterol, nonesterified fatty acids, and thiobarbituric acid-reactive substances.
Findings: Rats fed a high-fat diet showed higher levels of thiobarbituric acid-reactive substances, triglycerides, and cholesterol than the control group (p<0.05). Dietary inclusion of carvone, especially at higher levels, could reverse the effects of a high-fat diet on thiobarbituric acid-reactive substances, cholesterol, and triglycerides (p<0.05).
Conclusion: Carvone can alleviate hepatic steatosis in animals with Nonalcoholic fatty liver disease.
Materials & Methods: Animals were grouped into four groups and studied for 42 days, including rats fed with 1) a control diet (Control), 2) a high-fat diet (HF), 3) HF+50mg/kg body weight of carvone (50 Carv) and HF+100mg/kg body weight of carvone (100 Carv). Animals were killed, and blood and liver samples were obtained to evaluate the biochemical analyses, including triglyceride, cholesterol, nonesterified fatty acids, and thiobarbituric acid-reactive substances.
Findings: Rats fed a high-fat diet showed higher levels of thiobarbituric acid-reactive substances, triglycerides, and cholesterol than the control group (p<0.05). Dietary inclusion of carvone, especially at higher levels, could reverse the effects of a high-fat diet on thiobarbituric acid-reactive substances, cholesterol, and triglycerides (p<0.05).
Conclusion: Carvone can alleviate hepatic steatosis in animals with Nonalcoholic fatty liver disease.
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