GMJ Medicine
eISSN : 2626-3041
Embase
Biosis Previews
description
Volume 3, Issue 4 (2024)
GMJM 2024, 3(4): 121-125 |
Back to browse issues page
Article Type:
Subject:
History
Received: 2024/03/25 | Accepted: 2024/09/6 | Published: 2024/10/12
Received: 2024/03/25 | Accepted: 2024/09/6 | Published: 2024/10/12
How to cite this article
Nazer M, Darvishi M, Qolampour A. Protective Role of Menthone against Indomethacin-induced Gastric Ulcers in Rat Model. GMJM 2024; 3 (4) :121-125
URL: http://gmedicine.de/article-2-236-en.html
URL: http://gmedicine.de/article-2-236-en.html
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Rights and permissions
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
1- “Department of Infectious Diseases” and “Hepatitis Research Center”, Lorestan University of Medical Sciences, Khorramabad, Iran
2- Infectious Diseases and Tropical Medicine Research Center, AJA University of Medical Sciences, Tehran, Iran
3- Department of General Surgery, Lorestan University of Medical Sciences, Khorramabad, Iran
2- Infectious Diseases and Tropical Medicine Research Center, AJA University of Medical Sciences, Tehran, Iran
3- Department of General Surgery, Lorestan University of Medical Sciences, Khorramabad, Iran
Abstract (520 Views)
Aims: The use of novel agents has been considered for the management of different diseases. Gastric ulcers are a common disease. This study aimed to evaluate the effects of menthone, a novel agent, on gastric ulcers in an Indomethacin-induced model rat.
Materials & Methods: Animals were divided into 3 groups: 1) a Control group that received only distilled water, 2) Animals were treated with 40mg/kg bw omeprazole (Omeprazole), and 3) Animals were treated with 40mg/kg bw menthone (Menthone). A dose of indomethacin (30mg/kg body weight) was administered per animal. Gastric secretions and antioxidant parameters were evaluated at the end of the trial.
Findings: It was observed that an increased ulcer index, gastric volume, malondialdehyde level, and decreased superoxide dismutase and pepsin activity in the control group in comparison to other groups (p<0.05). The use of menthone and Omeprazole could alleviate the effects of indomethacin.
Conclusion: Menthone may not have positive effects similar to Omeprazole, but it could attenuate the effects of indomethacin.
Materials & Methods: Animals were divided into 3 groups: 1) a Control group that received only distilled water, 2) Animals were treated with 40mg/kg bw omeprazole (Omeprazole), and 3) Animals were treated with 40mg/kg bw menthone (Menthone). A dose of indomethacin (30mg/kg body weight) was administered per animal. Gastric secretions and antioxidant parameters were evaluated at the end of the trial.
Findings: It was observed that an increased ulcer index, gastric volume, malondialdehyde level, and decreased superoxide dismutase and pepsin activity in the control group in comparison to other groups (p<0.05). The use of menthone and Omeprazole could alleviate the effects of indomethacin.
Conclusion: Menthone may not have positive effects similar to Omeprazole, but it could attenuate the effects of indomethacin.
Keywords:
| | Full-Text (HTML) (87 Views)
References
1. Khazaei M, Salehi H. Protective effect of Falcaria vulgaris extract onethanol induced gastric ulcer in rat. Iranian J Pharmacol Ther. 2006;5:1-4. [Persian] [Link]
2. Sonnenberg A. Geographic and temporal variations in the occurrence of peptic ulcer disease. Scand J Gastroenterol. 1985;110:11-24. [Link] [DOI:10.3109/00365528509095826]
3. Shristi B, Neha J, Indu BP, Rajesh G. A review on some Indianmedicinal plants for antiulcer activity.J Sci Res Pharm. 2012;1:6-9. [Link]
4. Dimaline R, Varro A. Attack and defense in the gastric epithelium-A Delicate Balance. Exp Physiol. 2007;92:591-601. [Link] [DOI:10.1113/expphysiol.2006.036483]
5. Spirt MJ. Stress-related mucosal disease: Risk factors and prophylactic therapy. Clin Ther. 2004;26:197-213. [Link] [DOI:10.1016/S0149-2918(04)90019-7]
6. Vonkeman HE, Klok RM, Postma MJ, Brouwers JRBJ, van de Laar MAFJ. Direct medical costs of serious gastrointestinal ulcers among users of NSAIDs. Drugs Aging. 2007;24:681-90. [Link] [DOI:10.2165/00002512-200724080-00005]
7. Guzmán-Gómez O, García-Rodríguez RV, Quevedo-Corona L, Pérez-Pastén-Borja R, Rivero-Ramírez NL, Ríos-Castro E, et al. Amelioration of ethanol-induced gastric ulcers in rats pretreated with phycobiliproteins of Arthrospira (Spirulina) Maxima. Nutrients. 2018;10:763-71. [Link] [DOI:10.3390/nu10060763]
8. Maity P, Biswas K, Chattopadhyay I, Banerjee RK, Bandyopadhyay U. The use of neem for controlling gastric hyperacidity and ulcer. Phytother Res. 2009;23(6):747-55. [Link] [DOI:10.1002/ptr.2721]
9. Loolaie M, Moasefi N, Rasouli H, Adibi H. Peppermint and its Functionality: A review. Arch Clin Microbiol. 2017;8(4:54):1-16. [Link]
10. Sayanti B, Susri RC, Subrata C, Sandip KB. Healing properties of some Indian medicinal plants against indomethacin-induced gastric ulceration of rats. J Clin Biochem Nutr. 2007;41(2):106-14. [Link] [DOI:10.3164/jcbn.2007015]
11. Sanyal AR, Denath OK, Bhattacharya SK, Gode KD. The effect of cyproheptadine on gastric acidity. Scandinavia: Scandinavian University Books Munksgoard;1971. [Link]
12. Corne SJ, Morrissey SM, Woods RJ. Proceedings: A method for the quantitative estimation of gastric barrier mucus. J Physiol.1974;242 (2):116-7. [Link]
13. Szabo S, Hollander D. Pathways of gastrointestinal protection and repair: Mechanisms of action of sucralfate. Am J Med.1985;86(6A):23-31. [Link] [DOI:10.1016/0002-9343(89)90153-8]
14. Marklund S, Marklund G. Involvement of superoxide anion radi-cal in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem.1974;47: 469-74. [Link] [DOI:10.1111/j.1432-1033.1974.tb03714.x]
15. Devasagayam TP, Tarachand U. Decreased lipid peroxidation in the rat kidney during gestation. Biochem Biophys Res Commun. 1987;145:134-8. [Link] [DOI:10.1016/0006-291X(87)91297-6]
16. Ajani EO, Sabiu S, Bamisaye FA, Adenigba BV, Awomoyi DD, Adeyanju MN. Hepatoprotective and antioxidative effect ofethanolic leaf extract of Langenariabreviflora (bitter gourd) onindomethacin-ulcerated rats. J Pharm Biological Sci. 2014;9(5):61-8. [Link]
17. Raji Y, Oyeyemi WA, Shittu ST, Bolarinwa AT. Gastro-protectiveeffect of methanol extract of Ficusasperifolia bark on indomethacin-induced gastric ulcer in rats. Nig J Physiol Sci. 2015;26(1):43-8. [Link]
18. Biplab A, Sudhir KY, Kshama R, Sandip KB, Subrata C. Black tea andtheaflavins assist healing of indomethacin-induced gastric ulcerationin mice by antioxidative action. Evid Based Complem Alt Med. 2011;11:11-22. [Link]
19. Lüllmann H, Mohr K, Ziegler A, Bieger D. Color atlas of pharmacology. 2nd ed. New York: Thieme Stuttgart. 2000. [Link]
20. Alanko J, Riutta A, Holm P, Mucha I, Vapatalo H, Metsa-Ketela T. Modulation of arachidonic acid metabolism by phenols: Relation totheir structure and antioxidant/prooxidant properties. Free RadicBiol Med. 1999;26(1-2):193-201. [Link] [DOI:10.1016/S0891-5849(98)00179-8]
21. Wolfe K, Wu X, Liu RH. Antioxidant activity of apple peels. J AgricFood Chem. 2003;51:609-14. [Link] [DOI:10.1021/jf020782a]
22. Halici M, Odabasoglu F, Suleyman H, Cakir A, Aslam A, Bayir Y. Effect of water extract of Usnealongissima on antioxidant enzymeactivity and mucosal damage caused by indomethacin in rats. Phytomed. 2005;12:656-62. [Link] [DOI:10.1016/j.phymed.2004.06.021]
23. Odabasoglu F, Cakir A, Suleyman H, Aslam A, Bayir Y, Halici M. Gas-troprotective and antioxidant effects of usnic acid on indomethacininduced gastric ulcer in rats. J Ethnopharmacol. 2006;103:59-65. [Link] [DOI:10.1016/j.jep.2005.06.043]
24. Tulassay Z, Stolte M, Sjölund M, Engstrand L, Butruk E, Malfer-theiner P, et al. Effect of esomeprazole triple therapy on eradicationrates of Helicobacter pylori, gastric ulcer healing and prevention ofrelapse in gastric ulcer patients. Eur J GastroenterolHepatol. 2008;20(6):526-36. [Link] [DOI:10.1097/MEG.0b013e3282f427ac]
25. Fornai M, Colucci R, Antonioli L, Awwad O, Ugolini C, Tuccori M, et al. Effects of esomeprazole on healing of nonsteroidalanti-inflammatory drug (NSAID)-induced gastric ulcers in the pres-ence of a continued NSAID treatment: characterization of molecular mechanisms. Pharmacol Res. 2011;63:59-67. [Link] [DOI:10.1016/j.phrs.2010.10.013]