Volume 3, Issue 2 (2024)                   GMJM 2024, 3(2): 71-75 | Back to browse issues page



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Rostami Mehr S, Gholizadeh Salmani R, Abbasi-Maleki S, Rasheed S, Haghipanah M. Beneficial Effects of Exercise on Brain-Derived Neurotrophic Factor in Subjects with Alzheimer; a Systematic Review. GMJM 2024; 3 (2) :71-75
URL: http://gmedicine.de/article-2-262-en.html
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1- Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
2- Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
3- Department of Medicine Emergency, Acharya Shree Bhikshu Hospital, Moti Nagar, New Delhi, India
4- International Center for Neuroscience Research, Institute for Intelligent Research, Tbilisi, Georgia
* Corresponding Author Address: International Center for Neuroscience Research, Institute for Intelligent Research, 15 Anton Katalikos Street, Tbilisi, Georgia. Postal Code: 0105 (motahareh.haghipanah@gmail.com)
Abstract   (283 Views)
Aims: There are treatments that seem to help maintain mental skills and reduce the effects of Alzheimer's disease. On the other hand, physical exercises can have a protective effect against deterioration. The level of BDNF decreases in AD, and the decrease in this factor is consistent with the decrease in hippocampal volume in this disease. This study aimed to evaluate the effects of exercises on Brain-Derived Neurotrophic Factor levels in patients with Alzheimer's.
Information & Methods: This study was conducted based on the PRISMA guidelines in 2023. English papers on the effects of exercises on BDNF levels in subjects with Alzheimer's were included. Unpublished papers, review papers, and studies with deficient information were not included. Keywords were searched in PubMed, Scopus, EuropePMC, Cochrane Central Database, Embase, and Web of Science databases. All the studies were managed with Endnote™ X9.2 software.  
Findings: Twelve papers were reviewed, comprising 4 human and 8 animal studies. The periods for human studies lasted 26 to 52 weeks. Animal studies lasted 4 to 13 weeks. The samples were collected from plasma in human studies, while most animal studies were conducted on the expression of BDNF in the hippocampus (n=6). Out of 12 papers, 3 human papers and 8 animal studies showed that exercises significantly increased the concentration of the expression of BDNF
Conclusion: Exercise positively improves and increases the expression and concentrations of Brain-Derived Neurotrophic Factor.