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Volume 4, Issue 2 (2025)
GMJM 2025, 4(2): 77-82 |
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Received: 2024/11/15 | Accepted: 2025/05/1 | Published: 2025/06/7
Received: 2024/11/15 | Accepted: 2025/05/1 | Published: 2025/06/7
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Abbasi Maleki S, Gholami M, Ghazanfari Hashemi M, Hossein Gholizadeh Salmani R, Moradikor N. Protective Effects of Black Cumin Nanophytosome in Rats Exposed to Chronic Stress. GMJM 2025; 4 (2) :77-82
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S. Abbasi Maleki1, M. Gholami2, M. Ghazanfari Hashemi3, R. Hossein Gholizadeh Salmani4, N. Moradikor *5
1- Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
2- Department of Pharmacology & Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
3- School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4- Department of Pathobiology, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran
5- International Center for Neuroscience Research, Institute for Intelligent Research, Tbilisi, Georgia
2- Department of Pharmacology & Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
3- School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4- Department of Pathobiology, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran
5- International Center for Neuroscience Research, Institute for Intelligent Research, Tbilisi, Georgia
Abstract (903 Views)
Aims: Stress occurs during life and causes psychological problems that must be treated. Consumption of plants and their derivations may decrease the negative effects of stress. This study aimed to evaluate the effects of black cumin nanophytosomes on behavioral responses, stress oxidative biomarkers, and brain-derived neurotrophic factor changes in rats exposed to chronic stress.
Materials & Methods: The rats were divided into six groups of non-stressed (negative control or NC) and stressed treated with 0mg/kg of cumin essential oil (stress) and 20mg/kg of cumin (20-C), 40mg/kg of cumin (40-C), 20mg/kg of cumin nanophytosome (20-CN) and 40mg/kg of cumin nanophytosome (40-CN). Anxiety and depression-like behaviors, brain-derived neurotrophic factor levels, ferric-reducing antioxidant power, malondialdehyde concentrations, superoxide dismutase, and glutathione peroxidase activities were assessed.
Findings: Stress increased anxiety and depression-like behaviors and malondialdehyde concentration while decreasing brain-derived neurotrophic factor levels, ferric-reducing antioxidant power, superoxide dismutase, and glutathione peroxidase concentrations compared with NC rats. Cumin decreased anxiety and depression-like behaviors and malondialdehyde concentration while increased brain-derived neurotrophic factor levels, ferric-reducing antioxidant power, superoxide dismutase, and glutathione peroxidase concentrations compared with rats in the stress group.
Conclusion: Cumin, especially in the highest concentrations and nanophytosome coatings, can manage stress and decrease psychological behaviors by increasing brain-derived neurotrophic factors and the activities of antioxidant enzymes.
Materials & Methods: The rats were divided into six groups of non-stressed (negative control or NC) and stressed treated with 0mg/kg of cumin essential oil (stress) and 20mg/kg of cumin (20-C), 40mg/kg of cumin (40-C), 20mg/kg of cumin nanophytosome (20-CN) and 40mg/kg of cumin nanophytosome (40-CN). Anxiety and depression-like behaviors, brain-derived neurotrophic factor levels, ferric-reducing antioxidant power, malondialdehyde concentrations, superoxide dismutase, and glutathione peroxidase activities were assessed.
Findings: Stress increased anxiety and depression-like behaviors and malondialdehyde concentration while decreasing brain-derived neurotrophic factor levels, ferric-reducing antioxidant power, superoxide dismutase, and glutathione peroxidase concentrations compared with NC rats. Cumin decreased anxiety and depression-like behaviors and malondialdehyde concentration while increased brain-derived neurotrophic factor levels, ferric-reducing antioxidant power, superoxide dismutase, and glutathione peroxidase concentrations compared with rats in the stress group.
Conclusion: Cumin, especially in the highest concentrations and nanophytosome coatings, can manage stress and decrease psychological behaviors by increasing brain-derived neurotrophic factors and the activities of antioxidant enzymes.
Keywords:
Anxiety [MeSH], Antioxidant [MeSH], Brain-Derived Neurotrophic Factor [MeSH], Cumin [MeSH], Nanophytosome [MeSH], Stress [MeSH]
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