Volume 3, Issue 3 (2024)                   GMJM 2024, 3(3): 1001-1007 | Back to browse issues page
Article Type:
Descriptive & Survey |



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Ghalami F, Etekochay M, Binutha H, Haghipanah M. The Relationship Between Pro-Inflammatory Cytokines and Growth Factors in Patients with Diabetic Foot Ulcers. GMJM 2024; 3 (3) :1001-1007
URL: http://gmedicine.de/article-2-374-en.html
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1- Mazandaran University of Medical Sciences, Sari, Iran
2- International Center for Neuroscience Research, Institute for Intelligent Research, Tbilisi, Georgia
Abstract   (102 Views)
Several factors are involved in the healing process of diabetic foot ulcers. Thus, the present study was conducted to evaluate the relationship between pro-inflammatory cytokines and growth factors in patients with diabetic foot ulcers. This study was conducted on three groups of subjects. The first group was men and women (n=30) with diabetes and diabetic foot ulcers referring clinical centers in Iran. Another group was including diabetic women and men patients (n=30) without ulcers. Third group was including healthy men and women (n=30). Blood samples were collected and assessed for the serum concentrations of TNF-α, IL-1β, IL-6, bFGF, IFN-γ, selenoprotein, PDGF, VEGF and GM-CSF with the help of specific kits. The results showed significant differences between groups for the serum concentrations of TNF-α (P=0.001), IL-1β (P=0.001), IL-6 (P=0.001), bFGF (P=0.001), IFN-γ (P=0.001), selenoprotein (P=0.001), PDGF (P=0.001), VEGF (P=0.001) and GM-CSF (P=0.001). The results showed the serum concentrations of TNF-α, IL-1β, IL-6, IFN-γ, PDGF, and GM-CSF were significantly higher in the patients with diabetes and foot ulcer, diabetes and healthy subjects, respectively. The results showed a positive correlation between pro-inflammatory cytokines, while a negative correlation was observed between pro-inflammatory cytokines with other variables. In conclusion, pro-inflammatory and inflammatory factors were significantly higher in those with diabetes and especially with diabetic ulcers. The concentration of factors can be considered for the treatment and as markers for the treatment of foot ulcers.