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Volume 4, Issue 3 (2025)
GMJM 2025, 4(3): 103-109 |
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Article Type:
Original Research
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Received: 2025/07/30
Accepted: 2025/09/25
Published: 2025/09/30
Accepted: 2025/09/25
Published: 2025/09/30
How to cite this article
Hoseinikhah S, Pazooki S, Jarineshin H, Fekrat F. Effect of Ondansetron in Preventing Spinal Anesthesia-Induced Hypotension in Pregnant Women Undergoing Elective Cesarean Section. GMJM 2025; 4 (3) :103-109
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1- Department of Anesthesiology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
* Corresponding Author Address: Shahid Mohammadi Hospital, Bandar Abbas, Iran. Postal Code: 7916613885 (alirezahosseinikhah@yahoo.com)
Abstract (268 Views)
Aims: Spinal anesthesia-induced hypotension is a major challenge during cesarean sections under spinal anesthesia. Ondansetron may be a good option for solving this complication. This study aimed to evaluate the effect of ondansetron in preventing spinal anesthesia-induced hypotension in pregnant women undergoing elective cesarean section.
Materials & Methods: This prospective clinical trial was conducted in 2023 with 120 pregnant women classified as ASA I or II. The women were divided into two groups: One group received 4mg of ondansetron diluted in 10ml saline, and the second group received 10ml of normal saline. Different parameters, including systolic and diastolic blood pressure, heart rate, and SpO2, were recorded at multiple time intervals. The incidence of nausea, vomiting, and shivering was also assessed.
Findings: The ondansetron group showed a significant reduction in systolic and diastolic blood pressure compared to the saline group at several intervals immediately following the block. The results did not show differences in heart rate between the two groups, except during recovery, when the normal saline group had a higher heart rate. The incidence of nausea and shivering was similar between groups, while vomiting was slightly less frequent in the ondansetron group; the difference was not statistically significant.
Conclusion: Ondansetron may temporarily reduce blood pressure following spinal anesthesia in pregnant women undergoing cesarean section. Further studies are needed to determine its role in preventing hypotension during spinal anesthesia and to explore its potential effects on other perioperative parameters.
Materials & Methods: This prospective clinical trial was conducted in 2023 with 120 pregnant women classified as ASA I or II. The women were divided into two groups: One group received 4mg of ondansetron diluted in 10ml saline, and the second group received 10ml of normal saline. Different parameters, including systolic and diastolic blood pressure, heart rate, and SpO2, were recorded at multiple time intervals. The incidence of nausea, vomiting, and shivering was also assessed.
Findings: The ondansetron group showed a significant reduction in systolic and diastolic blood pressure compared to the saline group at several intervals immediately following the block. The results did not show differences in heart rate between the two groups, except during recovery, when the normal saline group had a higher heart rate. The incidence of nausea and shivering was similar between groups, while vomiting was slightly less frequent in the ondansetron group; the difference was not statistically significant.
Conclusion: Ondansetron may temporarily reduce blood pressure following spinal anesthesia in pregnant women undergoing cesarean section. Further studies are needed to determine its role in preventing hypotension during spinal anesthesia and to explore its potential effects on other perioperative parameters.