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Volume 4, Issue 1 (2025)
GMJM 2025, 4(1): 19-23 |
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Received: 2024/08/27 | Accepted: 2025/02/2 | Published: 2025/03/15
Received: 2024/08/27 | Accepted: 2025/02/2 | Published: 2025/03/15
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Davoodi M, Ahmed F, Panizai M, Obeidavi Z. Effect of Nano-Phytosome of Quercetin on Mice Liver Infected with Plasmodium berghei. GMJM 2025; 4 (1) :19-23
URL: http://gmedicine.de/article-2-245-en.html
URL: http://gmedicine.de/article-2-245-en.html
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1- Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
2- Livestock and Dairy Development Department Balochistan, Quetta, Pakistan
3- Lorestan University of Medical Sciences, Khorramabad, Iran
2- Livestock and Dairy Development Department Balochistan, Quetta, Pakistan
3- Lorestan University of Medical Sciences, Khorramabad, Iran
Abstract (1108 Views)
Aims: Malaria is one of most important diseases especially in tropical regions. Flavonoids are known to have beneficial properties that could be profitable. This study aimed to evaluate the effects of nano-phytosomes of Quercetin on liver damages of mice infected with Plasmodium berghei.
Materials & Methods: A total of 60 male BALB/c mice were intra-peritoneally infected by administration of 106 P. berghei-infected RBCs. Animals were acclimatized for 7 days and divided into 5 groups; 0.9% isotonic saline (as negative control), saline treated (as positive control), 2mg/kg of Hydroxychloroquine sulfate treated for 4 days (HF), 10mg/kg of nano-phytosomes of Quercetin treated for 4 days (NQ), and 10mg/kg of nano-phytosomes of Quercetin + 2mg/kg of Hydroxychloroquine sulfate for 4 days (NQ+HF). Histo-pathological parameters and pro-inflammatory cytokines were evaluated.
Findings: Administration of P. berghei could increase the scores for histo-pathological parameters and levels of pro-inflammatory cytokines (p<0.0001). Administration of Hydroxychloroquine sulfate and nano-phytosomes of Quercetin could alleviate adverse effects of P. berghei on histo-pathological parameters (p<0.05).
Conclusion: A combination of nano-phytosomes of Quercetin and Hydroxychloroquine sulfate shows the best effect on treatment of Plasmodium berghei infections.
Materials & Methods: A total of 60 male BALB/c mice were intra-peritoneally infected by administration of 106 P. berghei-infected RBCs. Animals were acclimatized for 7 days and divided into 5 groups; 0.9% isotonic saline (as negative control), saline treated (as positive control), 2mg/kg of Hydroxychloroquine sulfate treated for 4 days (HF), 10mg/kg of nano-phytosomes of Quercetin treated for 4 days (NQ), and 10mg/kg of nano-phytosomes of Quercetin + 2mg/kg of Hydroxychloroquine sulfate for 4 days (NQ+HF). Histo-pathological parameters and pro-inflammatory cytokines were evaluated.
Findings: Administration of P. berghei could increase the scores for histo-pathological parameters and levels of pro-inflammatory cytokines (p<0.0001). Administration of Hydroxychloroquine sulfate and nano-phytosomes of Quercetin could alleviate adverse effects of P. berghei on histo-pathological parameters (p<0.05).
Conclusion: A combination of nano-phytosomes of Quercetin and Hydroxychloroquine sulfate shows the best effect on treatment of Plasmodium berghei infections.
Keywords:
Malaria [MeSH], Pro-inflammatory Cytokines [MeSH], Nano-Phytosomes [MeSH], Quercetin [MeSH], Liver Damages [MeSH]
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