GMJ Medicine
eISSN : 2626-3041
Embase
Biosis Previews
description
Volume 4, Issue 2 (2025)
GMJM 2025, 4(2): 77-82 |
Back to browse issues page
Article Type:
Subject:
History
Received: 2024/11/15 | Accepted: 2025/05/1 | Published: 2025/06/7
Received: 2024/11/15 | Accepted: 2025/05/1 | Published: 2025/06/7
How to cite this article
Abbasi Maleki S, Gholami M, Ghazanfari Hashemi M, Hossein Gholizadeh Salmani R, Moradikor N. Protective Effects of Black Cumin Nanophytosome in Rats Exposed to Chronic Stress. GMJM 2025; 4 (2) :77-82
URL: http://gmedicine.de/article-2-263-en.html
URL: http://gmedicine.de/article-2-263-en.html
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Rights and permissions
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Authors
S. Abbasi Maleki1, M. Gholami2, M. Ghazanfari Hashemi3, R. Hossein Gholizadeh Salmani4, N. Moradikor *5
1- Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
2- Department of Pharmacology & Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
3- School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4- Department of Pathobiology, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran
5- International Center for Neuroscience Research, Institute for Intelligent Research, Tbilisi, Georgia
2- Department of Pharmacology & Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
3- School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4- Department of Pathobiology, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran
5- International Center for Neuroscience Research, Institute for Intelligent Research, Tbilisi, Georgia
Abstract (906 Views)
Aims: Stress occurs during life and causes psychological problems that must be treated. Consumption of plants and their derivations may decrease the negative effects of stress. This study aimed to evaluate the effects of black cumin nanophytosomes on behavioral responses, stress oxidative biomarkers, and brain-derived neurotrophic factor changes in rats exposed to chronic stress.
Materials & Methods: The rats were divided into six groups of non-stressed (negative control or NC) and stressed treated with 0mg/kg of cumin essential oil (stress) and 20mg/kg of cumin (20-C), 40mg/kg of cumin (40-C), 20mg/kg of cumin nanophytosome (20-CN) and 40mg/kg of cumin nanophytosome (40-CN). Anxiety and depression-like behaviors, brain-derived neurotrophic factor levels, ferric-reducing antioxidant power, malondialdehyde concentrations, superoxide dismutase, and glutathione peroxidase activities were assessed.
Findings: Stress increased anxiety and depression-like behaviors and malondialdehyde concentration while decreasing brain-derived neurotrophic factor levels, ferric-reducing antioxidant power, superoxide dismutase, and glutathione peroxidase concentrations compared with NC rats. Cumin decreased anxiety and depression-like behaviors and malondialdehyde concentration while increased brain-derived neurotrophic factor levels, ferric-reducing antioxidant power, superoxide dismutase, and glutathione peroxidase concentrations compared with rats in the stress group.
Conclusion: Cumin, especially in the highest concentrations and nanophytosome coatings, can manage stress and decrease psychological behaviors by increasing brain-derived neurotrophic factors and the activities of antioxidant enzymes.
Materials & Methods: The rats were divided into six groups of non-stressed (negative control or NC) and stressed treated with 0mg/kg of cumin essential oil (stress) and 20mg/kg of cumin (20-C), 40mg/kg of cumin (40-C), 20mg/kg of cumin nanophytosome (20-CN) and 40mg/kg of cumin nanophytosome (40-CN). Anxiety and depression-like behaviors, brain-derived neurotrophic factor levels, ferric-reducing antioxidant power, malondialdehyde concentrations, superoxide dismutase, and glutathione peroxidase activities were assessed.
Findings: Stress increased anxiety and depression-like behaviors and malondialdehyde concentration while decreasing brain-derived neurotrophic factor levels, ferric-reducing antioxidant power, superoxide dismutase, and glutathione peroxidase concentrations compared with NC rats. Cumin decreased anxiety and depression-like behaviors and malondialdehyde concentration while increased brain-derived neurotrophic factor levels, ferric-reducing antioxidant power, superoxide dismutase, and glutathione peroxidase concentrations compared with rats in the stress group.
Conclusion: Cumin, especially in the highest concentrations and nanophytosome coatings, can manage stress and decrease psychological behaviors by increasing brain-derived neurotrophic factors and the activities of antioxidant enzymes.
Keywords:
Anxiety [MeSH], Antioxidant [MeSH], Brain-Derived Neurotrophic Factor [MeSH], Cumin [MeSH], Nanophytosome [MeSH], Stress [MeSH]
| | Full-Text (HTML) (104 Views)
References
1. Sandi C, Haller J. Stress and the social brain: Behavioural effects and neurobiological mechanisms. Nat Rev Neurosci. 2015;16(5):290-304. [Link] [DOI:10.1038/nrn3918]
2. Dai S, Mo Y, Wang Y, Xiang B, Liao Q, Zhou M, et al. Chronic stress promotes cancer development. Front Oncol. 2020;10:1492. [Link] [DOI:10.3389/fonc.2020.01492]
3. Liu WZ, Zhang WH, Zheng ZH, Zou JX, Liu XX, Huang SH, et al. Identification of a prefrontal cortex-to-amygdala pathway for chronic stress-induced anxiety. Nat commu. 2020;11(1):2221. [Link] [DOI:10.1038/s41467-020-15920-7]
4. Robinson OJ, Krimsky M, Lieberman L, Allen P, Vytal K, Grillon C. Towards a mechanistic understanding of pathological anxiety: The dorsal medial prefrontal-amygdala 'aversive amplification'circuit in unmedicated generalized and social anxiety disorders. Lancet Psychiatry. 2014;1(4):294. [Link] [DOI:10.1016/S2215-0366(14)70305-0]
5. Juszczyk G, Mikulska J, Kasperek K, Pietrzak D, Mrozek W, Herbet M. Chronic stress and oxidative stress as common factors of the pathogenesis of depression and Alzheimer's disease: The role of antioxidants in prevention and treatment. Antioxidants. 2021;10(9):1439. [Link] [DOI:10.3390/antiox10091439]
6. Jesulola E, Micalos P, Baguley IJ. Understanding the pathophysiology of depression: From monoamines to the neurogenesis hypothesis model-are we there yet?. Behav Brain Res. 2018;341:79-90. [Link] [DOI:10.1016/j.bbr.2017.12.025]
7. Bekinschtein P, Cammarota M, Medina JH. BDNF and memory processing. Neuropharmacology. 2014;76:677-83. [Link] [DOI:10.1016/j.neuropharm.2013.04.024]
8. Alzoubi KH, Abdel-Hafiz L, Khabour OF, El-Elimat T, Alzubi MA, Alali FQ. Evaluation of the effect of Hypericum triquetrifolium turra on memory impairment induced by chronic psychosocial stress in rats: Role of BDNF. Drug Des Devel. 2020;14:5299-314. [Link] [DOI:10.2147/DDDT.S278153]
9. Yimer EM, Tuem KB, Karim A, Ur-Rehman N, Anwar F. Nigella sativa L. (Black Cumin): A promising natural remedy for wide range of illnesses. Evid Based Complement Alternat Med. 2019;2019:1528635. [Link] [DOI:10.1155/2019/1528635]
10. Hannan MA, Rahman MA, Sohag AAM, Uddin MJ, Dash R, Sikder MH, et al. Black Cumin (Nigella sativa L.): A comprehensive review on phytochemistry, health benefits, molecular pharmacology, and safety. Nutrients. 2021;13(6):1784. [Link] [DOI:10.3390/nu13061784]
11. Amiri A, Mousakhani-Ganjeh A, Amiri Z, Guo YG, Singh AP, Kenari RE. Fabrication of cumin loaded-chitosan particles: Characterized by molecular, morphological, thermal, antioxidant and anticancer properties as well as its utilization in food system. Food Chem. 2020;310:125821. [Link] [DOI:10.1016/j.foodchem.2019.125821]
12. Mughal SS. A review on potential antioxidant effects of Cumin (Cuminum cyminum), phytochemical profile and its uses. GSJ. 2021;8(9):1-19. [Link] [DOI:10.22541/au.166401164.45578619/v1]
13. Gueffai A, Gonzalez-Serrano DJ, Christodoulou MC, Orellana-Palacios JC, Ortega MLS, Ouldmoumna A, et al. Phenolics from defatted black cumin seeds (Nigella sativa L.): Ultrasound-assisted extraction optimization, comparison, and antioxidant activity. Biomolecules. 2022;12(9):1311. [Link] [DOI:10.3390/biom12091311]
14. Cañedo-Ayala M, Rice DB, Levis B, Carrier ME, Cumin J, Malcarne VL, et al. Scleroderma Caregiver Advisory Committee. Factors associated with symptoms of depression among informal caregivers of people with systemic sclerosis: A cross-sectional study. Disabil Rehabil. 42(3):394-99. [Link] [DOI:10.1080/09638288.2018.1500647]
15. Kannan R, George S, Chakrapani BPS, Maliakel B, Ittiyavirah S, Krishnakumar I. Thymoquinone-rich black cumin oil improves sleep quality, alleviates anxiety/stress on healthy subjects with sleep disturbances-A pilot polysomnography study. J Herb Med. 2022;32:100507. [Link] [DOI:10.1016/j.hermed.2021.100507]
16. Ittiyavirah SP, Ramalingam K, Sathyan A, Rajasree R, Kuruniyan MS, Quadri SA, et al. Thymoquinone-rich black cumin oil attenuates ibotenic acid-induced excitotoxicity through glutamate receptors in Wistar rats. Saudi Pharm J. 2022;30(12):1781-90. [Link] [DOI:10.1016/j.jsps.2022.10.007]
17. Komeil IA, Abdallah OY, El-Refaie WM. Surface modified genistein phytosome for breast cancer treatment: In-vitro appraisal, pharmacokinetics, and in-vivo antitumor efficacy. Eur J Pharm Biopharm. 2022;179:106297. [Link] [DOI:10.1016/j.ejps.2022.106297]
18. Mohammadi M, Hamishehkar H, Piruzifard MK. Nanophytosome as a promising carrier for improving cumin essential oil properties. Food Biosci. 2021;42:101079. [Link] [DOI:10.1016/j.fbio.2021.101079]
19. Moradi-Kor N, Ghanbari A, Rashidipour H, Yousefi B, Bandegi AR, Rashidy-Pour A. Beneficial effects of Spirulina platensis, voluntary exercise and environmental enrichment against adolescent stress induced deficits in cognitive functions, hippocampal BDNF and morphological remolding in adult female rats. Horm Behav. 2019;112:20-31. [Link] [DOI:10.1016/j.yhbeh.2019.03.004]
20. Moradi-Kor N, Dadkhah M, Ghanbari A, Rashidipour H, Bandegi AR, Barati M, et al. Protective effects of spirulina platensis, voluntary exercise and environmental interventions against adolescent stress-induced anxiety and depressive-like symptoms, oxidative stress and alterations of BDNF and 5HT-3 receptors of the prefrontal cortex in female rats. Neuropsychiatr Dis Treat. 2020;16:1777-94. [Link] [DOI:10.2147/NDT.S247599]
21. Moutinho ILD, Maddalena NCP, Roland RK, Lucchetti ALG, Tibiriçá SHC, Ezequiel ODS, et al. Depression, stress and anxiety in medical students: A cross-sectional comparison between students from different semesters. Rev Assoc Med Bras. 2017;63:21-8. [Link] [DOI:10.1590/1806-9282.63.01.21]
22. Wahed WYA, Hassan SK. Prevalence and associated factors of stress, anxiety and depression among medical Fayoum University students. Alexandria J Med. 2017;53(1):77-84. [Link] [DOI:10.1016/j.ajme.2016.01.005]
23. Aloufi MA, Jarden RJ, Gerdtzm MF, Kapp S. Reducing stress, anxiety and depression in undergraduate nursing students: Systematic review. Nurse Educ Today. 2017;102,104877 [Link] [DOI:10.1016/j.nedt.2021.104877]
24. Hormozi M, Mirzaei R, Nakhaee A, Izadi S, Dehghan Haghighi J. The biochemical effects of occupational exposure to lead and cadmium on markers of oxidative stress and antioxidant enzymes activity in the blood of glazers in tile industry. Toxicol Ind Health. 2018;34(7):459-67. [Link] [DOI:10.1177/0748233718769526]
25. Omari Z, Kazunori S, Sabti M, Bejaoui M, Hafidi A, Gadhi C, et al. Dietary administration of cumin-derived cuminaldehyde induce neuroprotective and learning and memory enhancement effects to aging mice. Aging (Albany NY). 2021;13(2):1671-85. [Link] [DOI:10.18632/aging.202516]